Aquaporin-1 Protein Expression of the Primary Tumor May Predict Cerebral Progression of Cutaneous Melanoma

Imrédi, Eleonóra; Liszkay, Gabriella; Kenessey, István; Plótár, Vanda; Gödény, Mária; Toth, Béla B.; Fedorcsák, Imre; Tı́már, József

doi:10.1007/s12253-018-0513-6

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…However, alteration of AQP1 expression has been associated with different tumors [8], including non-melanoma skin cancer (NMSC) and melanoma, though its role is still not completely clear. Indeed, in vivo studies conducted on a mouse model by Nicchia et al [9] showed that AQP1 is associated with poor prognosis in MM, while Imredi et al [10] showed, for the first time, that the overexpression of AQP1 can be associated with increased mortality and accelerated metastatic progression in MM, assuming a possible association between AQP1 and BRAF V600E mutation [10][11][12]. Conversely, Osorio et al [13] have found that AQP1 expression is downregulated in NMSC and melanoma compared to control skin and benign nevi.…”

Section: Introductionmentioning

confidence: 99%

Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome

Camillo,

Esposto,

Gironi

et al. 2023

JCM

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Aquaporins (AQPs) are small transmembrane proteins able to facilitate the passive transport of water and small molecules throughout cells. Several studies have demonstrated that modulation of AQPs’ expression contributes to cancer development and progression. However, to date, very little is known about their involvement in malignant melanoma (MM) progression. In this retrospective observational study, we evaluated the correlation between AQP1, -8, and -9 expression and the clinical outcomes of 58 patients diagnosed with MM from 2014 to 2016, of which 14 were diagnosed as nodular melanoma (NM) and 44 as superficial spreading melanoma (SSM). In general, we found that AQPs were more highly expressed in SSM than NM, suggesting a potential correlation with prognosis. While analyzing the expression of each AQP, we discovered that AQP1 was associated with a specific body site and low mitotic index, AQP8 with a negative sentinel lymph node, and AQP9 with the Breslow thickness and lack of ulcerations. Together with the survival analysis performed in this study, our results suggest that the expression of AQP1, -8, and -9 could be correlated with a better prognosis for malignant melanoma.

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Section: Introductionmentioning

confidence: 99%

Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome

Camillo,

Esposto,

Gironi

et al. 2023

JCM

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“…Interaction with diverse stromal cells can activate pro-invasive programs such as an epithelial-to-mesenchymal transition in some primary tumor cells, leading to metastatic dissemination 6,7 . Dynamic changes in the tumor microenvironment can also lead to immune surveillance escape 8,9 and are predictive of melanoma prognosis 10 . Within the tumor microenvironment, tumorreactive T lymphocytes play a central role in suppressing tumor growth by infiltrating into malignant lesions and selectively killing cancer cells 11,12 .…”

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confidence: 99%

Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis

et al. 2021

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Melanoma is the most lethal skin malignancy, driven by genetic and epigenetic alterations in the complex tumour microenvironment. While large-scale molecular profiling of melanoma has identified molecular signatures associated with melanoma progression, comprehensive systems-level modeling remains elusive. This study builds up predictive gene network models of molecular alterations in primary melanoma by integrating large-scale bulk-based multi-omic and single-cell transcriptomic data. Incorporating clinical, epigenetic, and proteomic data into these networks reveals key subnetworks, cell types, and regulators underlying melanoma progression. Tumors with high immune infiltrates are found to be associated with good prognosis, presumably due to induced CD8+ T-cell cytotoxicity, via MYO1F-mediated M1-polarization of macrophages. Seventeen key drivers of the gene subnetworks associated with poor prognosis, including the transcription factor ZNF180, are tested for their pro-tumorigenic effects in vitro. The anti-tumor effect of silencing ZNF180 is further validated using in vivo xenografts. Experimentally validated targets of ZNF180 are enriched in the ZNF180 centered network and the known pathways such as melanoma cell maintenance and immune cell infiltration. The transcriptional networks and their critical regulators provide insights into the molecular mechanisms of melanomagenesis and pave the way for developing therapeutic strategies for melanoma.

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Membrane Transporters and Channels in Melanoma

Böhme

Schönherr

Eberle

et al. 2020

Reviews of Physiology, Biochemistry and Pharmacology

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Aquaporin-1 Protein Expression of the Primary Tumor May Predict Cerebral Progression of Cutaneous Melanoma

Cited by 7 publications

References 26 publications

Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome

Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome

Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis

Membrane Transporters and Channels in Melanoma

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