Aquagenic pruritus induced by clomipramine

Mendlowicz, Mauro V.; Lima, João Luiz Lopes; Fontenelle, Leonardo F.

doi:10.1016/j.genhosppsych.2013.01.016

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Other reported underlying conditions that may induce AP include juvenile xanthogranuloma, myelodysplastic syndrome, T‐cell non‐Hodgkin's lymphoma, hepatitis C infection, and idiopathic hypereosinophilic syndrome . Iatrogenic AP has been reported in patients treated with antimalarial and antidepressant drugs such as bupropion and clomipramine .…”

Section: Aquagenic Pruritusmentioning

confidence: 99%

Aquagenic cutaneous disorders

Wang

Zhao

Luo

et al. 2017

J Deutsche Derma Gesell

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SummaryAquagenic cutaneous disorders, which include aquagenic urticaria, aquagenic pruritus, and aquagenic acrokeratoderma, are a group of rare diseases characterized by skin lesions or discomfort induced by brief contact with water. Aquagenic urticaria is characterized by pruritic wheals that occur at the sites of water contact, either immediately or within minutes, and disappear within 30-60 min after water removal. Aquagenic pruritus presents with severe pruritus or a stinging, tingling, or burning sensation without any visible skin changes. These symptoms occur immediately or within minutes after the skin is exposed to water, lasting for one hour or longer. Aquagenic acrokeratoderma usually presents with whitish papules and plaques, edema, and hyperwrinkling within 2-20 min after brief exposure to water; symptoms disappear within minutes to one hour after drying. The pathomechanisms of these diseases are not yet fully understood, and their diagnosis is primarily based on clinical features. Treatment remains a challenge. Herein, we review the literature regarding these unusual disorders.

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Section: Aquagenic Pruritusmentioning

confidence: 99%

Aquagenic cutaneous disorders

Wang

Zhao

Luo

et al. 2017

J Deutsche Derma Gesell

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“…Weitere Störungen, die AP induzieren können, sind Xanthogranuloma juvenile, myelodysplastisches Syndrom, T‐Zell‐Non‐Hodgkin‐Lymphom, Hepatitis C und idiopathisches hypereosinophiles Syndrom . Bei Patienten, die mit Malariamedikamenten oder Antidepressiva wie Bupropion oder Clomipramin behandelt werden, wurde iatrogener AP beobachtet .…”

Section: Aquagener Pruritusunclassified

Aquagene Hauterkrankungen

Wang

Zhao

Luo

et al. 2017

J Deutsche Derma Gesell

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“…The sample was prepared and histochemical studies done for acetycholinesterase (ACHE) activity. Their finding indicated that acetylcholine activation might support clinical diagnosis of aquagenic pruritus [21].…”

Section: Acetylcholine Releasementioning

confidence: 99%

“…It is usually a diagnosis of exclusion, when possible diseases that can result in pruritus of the affected patient have been ruled out. These include effects of medication such as bupropion, chloroquine, and clomipramine [21]; systemic diseases such as polycythemia vera, and urticaria [9]. Aquagenic pruritus diagnosis satisfies certain clinical conditions [7,34]:…”

Section: Diagnosis Of Aquagenic Pruritusmentioning

confidence: 99%

Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine

EL¹

2017

CAJPH

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Aquagenic pruritus is a common dermatological problem with prevalence as high as 26.5% in some locations of the world. Pruritus is the major symptom manifesting as prick-like, burning or biting sensation after contact with water. Histamine from mast cells has been the main culprit responsible for the itching associated with this problem and some patients are relieved by anti-histamines when given. However, anti-histamines do not relieve symptoms of aquagenic pruritus when given to some other groups of patients; implying that other risk factors or chemical mediators outside histamine may be responsible for this problem. Recently, other associated risk factors have been enumerated from various scientific researches to be responsible for this health problem. This article reviews these other risk factors that are linked up to the pathophysiology of aquagenic pruritus and the possible pharmacological intervention adopted by various authors and researchers globally.

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Aquagenic pruritus induced by clomipramine

Cited by 8 publications

References 15 publications

Aquagenic cutaneous disorders

Aquagenic cutaneous disorders

Aquagene Hauterkrankungen

Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine

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