Aquagenic keratoderma

Betlloch, Isabel; Vergara, Gloria; Albares, MP; Pascual, J-C; Silvestre, J.F.; Botella, Rafael

doi:10.1046/j.1468-3083.2003.00799.x

Cited by 50 publications

(77 citation statements)

References 3 publications

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“…Besides the initial term ‘transient reactive papulotranslucent acrokeratoderma’ [2], other authors renamed this entity ‘aquagenic palmoplantar keratoderma’ [1, 8], ‘aquagenic wrinkling of the palms’ [9], ‘aquagenic syringeal acrokeratoderma’ [3, 4] or ‘aquagenic keratoderma’ [5] emphasizing either the triggering agent or the presumed site of action. Nomenclature with attributes such as ‘instant’, ‘idiopathic’ and ‘transient’ stressed the rapid development of symptoms after contact with water and the short-term persistence of symptoms [10].…”

Section: Discussionmentioning

confidence: 99%

“…A search of the English literature using all proposed terms of TAPH identified 24 cases in the dermatological literature which are summarized in table 1[1,2,3, 5,8,9,10,11,12,13,14,15,16,17,18,19]. However, not included are 12 additional cases of TAPH associated with CF which were published in the 1970s by paediatricians, but lack detailed clinical information [20, 21].…”

Section: Discussionmentioning

confidence: 99%

“…To describe this phenomenon which may be easily distinguished from physiologic water-induced skin wrinkling, several terms have been used in the literature, e.g. aquagenic papulotranslucent or syringeal acrokeratoderma, hand-in-the-bucket sign, and others [1,2,3,4,5]. While the exact pathophysiologic mechanism of TAPH is currently unknown, increased water absorption due to an abnormal quantity and/or composition of sweat and the decreased barrier function of the epidermis seem to be important factors [4].…”

Section: Introductionmentioning

confidence: 99%

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Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

et al. 2008

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Transient aquagenic palmar hyperwrinkling (TAPH) is a rarely reported cutaneous condition clinically characterized by swelling and hyperwrinkling of the palms, and associated with burning sensations after briefly immersing the hands in water. Upon the withdrawal of water, the symptoms rapidly disappear. We report on a 10-year-old boy with type I diabetes, who developed the typical symptoms of TAPH concomitantly with the onset of palmar hyperhidrosis. Determination of the sodium chloride concentration of the sweat revealed elevated levels. Subsequent screening for the most common mutations of the gene responsible for cystic fibrosis (CF) was negative. Review of the literature shows that TAPH may develop in conditions of increased water absorption due to an increased sweat quantity, such as hyperhidrosis, or an increased sweat electrolyte concentration, such as CF. In the majority of reported cases TAPH has been associated with CF; therefore, it is a cutaneous sign, which should be recognized by dermatologists, and patients should be referred for evaluation of the sodium chloride concentration of the sweat.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

et al. 2008

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“…Two recent reports have found a high prevalence of AWP in an American CF population [6] and a French CF population [7]. AWP has been described under numerous synonyms including ‘transient reactive papulotranslucent keratoderma’ [8,9,10], ‘aquagenic palmoplantar keratoderma’ [1], ‘aquagenic keratoderma’ [11], ‘aquagenic syringeal acrokeratoderma’ [12], ‘transient palmar hyperwrinkling’ [4] and ‘wrinkling of the skin’ [2,13]. …”

Section: Introductionmentioning

confidence: 99%

Aquagenic Wrinkling of the Palms in an Adult Cystic Fibrosis Population

Tolland

Boyle²,

Hall³

et al. 2010

Dermatology

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Background: Aquagenic wrinkling of the palms (AWP) is a rare condition characterised by the development of oedema and excessive wrinkling of the palms following exposure to water. It has frequently been associated with cystic fibrosis (CF). Early reports of AWP have only been case reports or small case series; there has only been one reported prevalence study of AWP in a CF population. Objective: To determine the incidence and characteristics of AWP in the adult CF population in Northern Ireland. Methods: 105 CF patients were interviewed. The patients were asked whether they noticed excess wrinkling of the hands when exposed to water. If they answered ‘yes’, further questions were asked regarding clinical characteristics. The atopic status, CF genotype and drug history were recorded for each patient. Formal testing of 7 patients was carried out. Results: Out of the 105 patients who were interviewed, 43 (41%) described AWP. Of the 43 patients with AWP, 20 were male and 23 were female. There was no association of AWP with genotype, atopy or concomitant drug intake. Conclusion: AWP appears to have an equal sex incidence, and the high number of cases in the population studied would suggest that this condition is underreported.

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“…2 The "hand-in-the bucket" sign, when patients submerge their hands in water to demonstrate the lesions, constitutes a clue to diagnosis. 3 Patients may report tightness, pruritus, mild pain, 4 Bellotch et al (1 case) 13 Katz et al (2 cases) 14 Neri et al (1 case) 15 Suchak et al (1 case) 16 Kocatürk et al (1 case) 17 Seitz et al (1 case) 9 Katz et al (1 case) 14 Baldwin et al (1 case) 18 Flann et al (1 case) 19 Kabashina et al (1 case) 20 Diba et al (1 case) 11 Bagazgoita et al (1 case) 6 Our case The last 3 cases responded to botulinum toxin injections…”

Section: Case Reportmentioning

confidence: 99%

Unilateral aquagenic keratoderma treated with botulinum toxin A

Houle

Dhaybi²,

Benohanian³

2010

J Dermatol Case Rep

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Background: Aquagenic keratoderma is a rare transient disease that occurs after water immersion and disappears shortly after drying. Most cases involve the palms and fingers bilaterally but it can also affect the soles. Few cases have been associated with drugs but its pathogenesis remains unclear.Main observation: We report a 60-year-old man with a 30-year-history of aquagenic keratoderma of the right palm without associated hyperhidrosis or history of drug intake. After unsuccessful treatment with 15% aluminium chloride hexahydrate gel, botulinum toxin A injections led to significant improvement within 2 weeks.Conclusions: To our knowledge, this case is the first report of idiopathic unilateral aquagenic keratoderma in the medical literature. It is the third report of successful treatment with botulinum toxin A which is in favor of a role of sweat glands in the pathogenesis of aquagenic keratoderma.

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Aquagenic keratoderma

Cited by 50 publications

References 3 publications

Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

Painful Wrinkles in the Bathtub: Association with Hyperhidrosis and Cystic Fibrosis

Aquagenic Wrinkling of the Palms in an Adult Cystic Fibrosis Population

Unilateral aquagenic keratoderma treated with botulinum toxin A

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