Aquagenic acrokeratoderma

Luo, Di‐Qing; Zhao, Yanyang; Zhang, Wujun; Wu, Li

doi:10.1111/j.1365-4632.2009.04304.x

Cited by 24 publications

(29 citation statements)

References 22 publications

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“…Abnormal barrier function in the stratum corneum due to transitory structural or functional alterations may result in increased absorption of water, leading to weakness of the eccrine duct walls with a dilated acrosyringium. Exacerbation of the condition with detergent exposure in one case report also supports this hypothesis [10]. Abnormal regulations of transmembrane channels such as aquaporin 3 and a role of weakness of eccrine duct walls have also been considered in the etiology of ASA.…”

Section: Discussionmentioning

confidence: 72%

Dermatoscopy as an Adjunctive Diagnostic Tool in Aquagenic Syringeal Acrokeratoderma

Sezer

Erkek²,

Duman³

et al. 2012

Dermatology

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Aquagenic syringeal acrokeratoderma (ASA) is a rare skin disorder of the palms and/or soles, characterized by whitish papules with occasional pruritus or pain sensation. Herein we report a 27-year-old man with a diagnosis of ASA based on clinical and histopathological features, and describe the dermatoscopic features consistent with threefold enlarged sweat duct pores compared with a normal-looking palmar skin area. As far as we are aware, dermatoscopic features of ASA have not been reported so far.

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Section: Discussionmentioning

confidence: 72%

Dermatoscopy as an Adjunctive Diagnostic Tool in Aquagenic Syringeal Acrokeratoderma

Sezer

Erkek²,

Duman³

et al. 2012

Dermatology

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“…Warm water is more rapidly effective than cold water [9]. Plantar involvement is occasionally observed [10], but rarely are the soles the only affected site.…”

Section: Introductionmentioning

confidence: 99%

Aquagenic Wrinkling of the Palms and Cystic Fibrosis: An Italian Study with Controls and Genotype-Phenotype Correlations

Chinazzo

Alessandri²,

Menoni

et al. 2014

Dermatology

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Aims: The primary aim was to determine the prevalence of aquagenic wrinkling of the palms (AWP) in patients with cystic fibrosis (CF) compared to controls, and secondarily to evaluate genotype-phenotype correlations among CF subjects found to have AWP. Methods: Fifty-eight patients with CF underwent a hand immersion test in tap water. Twenty-three of their CF carrier relatives and 7 subjects with a negative genetic test for CF were recruited as controls. Secondary analyses explored associations with genotype, pulmonary function, and sweat electrolyte levels in all subjects with and without AWP. Additional information about atopic diathesis, hyperhidrosis of the palms and drug intake were also collected. Results: Thirty-one of the patients with CF (53.4%) exhibited AWP, in contrast to only 2 carriers (8.7%) and none in the control group. No correlation was found between CF genotype and AWP score severity. Twenty-three (39.7%) CF patients reported a history of hyperhidrosis, and in 17 of them (74%) AWP had been provoked. No correlation with history of atopy and lung function was noted. The difference between CF patients with hyperhidrosis and those without was highly significant (p = 0.016). Salt concentrations were significantly higher in patients with AWP. Conclusions: AWP is linked to CF and its diagnosis should lead the patients to a genetic or sweat test for CF. We found a significant association with hyperhidrosis and sweat electrolytes which supports the ‘hyperconcentrated sweat' pathogenetic theory of AWP.

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“…[3] The morphological changes develop after contact with water, with gradual improvement within 2-20 min. [3] This accentuation of skin lesions after water immersion is known as the “hand-in-the-bucket” sign and is considered diagnostic. [9]…”

Section: Discussionmentioning

confidence: 99%

Aquagenic keratoderma. Two new case reports and a new hypothesis

Tchernev¹,

Semkova²,

Cardoso³

et al. 2014

Indian Dermatol Online J

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Aquagenic keratoderma has been described as a transient condition affecting predominantly young females and defined clinically by the appearance of palmar hyper-wrinkling accentuated after immersion in water. We present two new cases with aquagenic palmoplantar acrokeratoderma – a child and a young male. A significant clinical improvement was achieved after topical treatment with aluminum salts. Aquagenic palmar keratoderma may be a clue to cystic fibrosis in adolescents and young adults. We developed a new hypothesis on its pathogenesis.

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Aquagenic acrokeratoderma

Abstract: AA may occur in both males and females and may involve the feet. Warm water triggers the lesions more rapidly than cold. Topical formalin 3% in alcohol and 3% potassium aluminium sulfate solution may be optional therapy.

Cited by 24 publications

References 22 publications

Dermatoscopy as an Adjunctive Diagnostic Tool in Aquagenic Syringeal Acrokeratoderma

Dermatoscopy as an Adjunctive Diagnostic Tool in Aquagenic Syringeal Acrokeratoderma

Aquagenic Wrinkling of the Palms and Cystic Fibrosis: An Italian Study with Controls and Genotype-Phenotype Correlations

Aquagenic keratoderma. Two new case reports and a new hypothesis

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