AQUAFAC 5 : AQUeous Functional group Activity Coefficients; application to alcohols and acids

Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as model compound

“…The most likely explanation for this discrepancy can be the effect of particle size, crystallinity and other molecular features of the sample [10,20] or the great differences in the applied experimental conditions. 30] 0.025-2600 Dexamethasone [11,29] 89.1-121.0 Diclofenac [8,12b,13] 0.6-2.4 Digoxin [11,29] 28.0-97.9 Estradiol [11,29] 0.16-5.00 Hydrocortisone [11,29] 280-359 Ibuprofen [8,[13][14][15] 20-80 Indomethacin [11,19] 4.00-14.0 Lidocaine [16][17][18][19] 2.30-4.60 Progesterone [11,29] 7.90-200 Riboflavine [11,29] 66.0-99.9…”

The correlation and prediction of the solubility of compounds in water using an amended solvation energy relationship

“…6,7 Because the reference state for solutes in these methods is the pure liquid, they require a knowledge of the solute enthalpy of fusion or an approximate mp correction term for solids. Another type of group contribution scheme is used in the AQUAFAC program, [8][9][10][11][12][13] which was applied to 970 compounds. 10 Again, either the entropy of fusion or the mp is needed for solid solutes.…”

Salt Solubility Products of Diprenorphine Hydrochloride, Codeine and Lidocaine Hydrochlorides and Phosphates – Novel Method of Data Analysis Not Dependent on Explicit Solubility Equations

“…e [24] f [16]. g [25] h [26] i [27] The solubility products are also affected significantly when I >> I ref .…”