Aqua-Art: A Demonstration of Hydrophilic and Hydrophobic Surfaces Fabricated by Plasma Enhanced Chemical Vapor Deposition

Flynn, Shauna P.; McKenna, Milena; Monaghan, Ruairi; Kelleher, Susan M.; Daniels, Stephen; MacCormac, Aoife

doi:10.1021/acs.jchemed.6b00474

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…The measurement was obtained at 0 V direct current (DC) bias voltage with a 1-kHz frequency across the DIDC biosensor. First, the sensor domain was triggered with the piranha solution at a 3:1 ratio (H 2 SO 4 :H 2 O 2 ) at 80 °C and then rinsed with deionized (DI) water to remove the reagents resulting in a hydrophilic surface as reported elsewhere. , After the activation process, the surface was coated with GrO (4 μL) at 1300 rpm via spin coating method (Figure A(ii)). Then, GrO onto the DIDC chip was annealed on a hot plate at 80 °C for 1 h. After the annealing process, EDC-NHS (4 μL; 0.4 and 0.1 M, respectively) chemistry was performed using an optimized process to generate the covalent conjugation of amine and carboxylic groups via amide bond formation represented in Figure A(iii).…”

Section: Fabrication Of Didc-based Sars-cov-2 Biosensormentioning

confidence: 99%

Ultrasensitive and Reusable Graphene Oxide-Modified Double-Interdigitated Capacitive (DIDC) Sensing Chip for Detecting SARS-CoV-2

et al. 2021

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This research reveals the promising functionalization of graphene oxide (GrO)-glazed double-interdigitated capacitive (DIDC) biosensing platform to detect severe acute respiratory syndrome coronavirus (SARS-CoV-2) spike (S1) proteins with enhanced selectivity and rapid response. The DIDC bioactive surface consisting of Pt/Ti featured SiO 2 substrate was fabricated using GrO/EDC-NHS/anti-SARS-CoV-2 antibodies (Abs) which is having layer-by-layer interface self-assembly chemistry method. This electroactive immune-sensing platform exhibits reproducibility and sensitivity with reference to the S1 protein of SARS-CoV-2. The outcomes of analytical studies confirm that GrO provided a desired engineered surface for Abs immobilization and amplified capacitance to achieve a wide detection range (1.0 mg/mL to 1.0 fg/mL), low limit of detection (1 fg/mL) within 3 s of response time, good linearity (18.56 nF/g), and a high sensitivity of 1.0 fg/mL. Importantly, the unique biochip was selective against blood-borne antigens and standby for 10 days at 5 °C. Our developed DIDC-based SARS-CoV-2 biosensor is suitable for point-of-care (POC) diagnostic applications due to portability and scaling-up ability. In addition, this sensing platform can be modified for the early diagnosis of severe viral infections using real samples.

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Section: Fabrication Of Didc-based Sars-cov-2 Biosensormentioning

confidence: 99%

Ultrasensitive and Reusable Graphene Oxide-Modified Double-Interdigitated Capacitive (DIDC) Sensing Chip for Detecting SARS-CoV-2

et al. 2021

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“…Surfaces with contact angles smaller than 90°are defined as hydrophilic, whereas those with contact angles larger than 90°are hydrophobic. [43][44][45] According to the Young-Dupré equation, [46] the more hydrophilic the contact between a solid and a liquid, the higher the work of adhesion as greater thermodynamic work is required to separate the liquid from the solid surface. [47,48] The contact angle of the uncoated outer surface of the MSR was initially about 104.2 ± 2.1°before the hydrophilic treatment, showing the inherent hydrophobicity of the silicone surface of the MSR; the corresponding work of adhesion was measured to be 54.9 ± 2.6 mJ m −2 .…”

Section: Fabrication and Characterization Of The Microrobotic Guidewirementioning

confidence: 99%

An Electromagnetically Controllable Microrobotic Interventional System for Targeted, Real‐Time Cardiovascular Intervention

Hwang

Jeon

Kim

et al. 2022

Adv Healthcare Materials

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Robotic magnetic manipulation systems offer a wide range of potential benefits in medical fields, such as precise and selective manipulation of magnetically responsive instruments in difficult‐to‐reach vessels and tissues. However, more preclinical/clinical studies are necessary before robotic magnetic interventional systems can be widely adopted. In this study, a clinically translatable, electromagnetically controllable microrobotic interventional system (ECMIS) that assists a physician in remotely manipulating and controlling microdiameter guidewires in real time, is reported. The ECMIS comprises a microrobotic guidewire capable of active magnetic steering under low‐strength magnetic fields, a human‐scale electromagnetic actuation (EMA) system, a biplane X‐ray imaging system, and a remote guidewire/catheter advancer unit. The proposed ECMIS demonstrates targeted real‐time cardiovascular interventions in vascular phantoms through precise and rapid control of the microrobotic guidewire under EMA. Further, the potential clinical effectiveness of the ECMIS for real‐time cardiovascular interventions is investigated through preclinical studies in coronary, iliac, and renal arteries of swine models in vivo, where the magnetic steering of the microrobotic guidewire and control of other ECMIS modules are teleoperated by operators in a separate control booth with X‐ray shielding. The proposed ECMIS can help medical physicians optimally manipulate interventional devices such as guidewires under minimal radiation exposure.

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“…Visually interesting demonstrations on surface wettability have been published in this journal. However, these demonstrations focused only on the chemical composition of the surface or solution to explain wettability. − The topography of surfaces is addressed in another laboratory article that utilizes biomimetic replication of superhydrophobic leaf surfaces to create superhydrophobic polymer molds . These laboratories and demonstrations explore either the effect of chemical modifications or the topological change of the surface on its wettability.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chemical and Physical Modifications on the Wettability of Polydimethylsiloxane Surfaces

et al. 2019

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The importance of understanding factors that contribute to surface wettability is highlighted in this new organic chemistry laboratory experiment, which aims to introduce the application of organic chemistry at the interface of polymer chemistry and material science. Polydimethylsiloxane (PDMS), a hydrophobic silicon-based rubber, is polymerized and molded onto templates of varying roughnesses and textures to introduce topology that changes surface hydrophilicity. The topological changes are assessed through optical microscopy imaging, and the wettability is analyzed by measuring the contact angle using an inexpensive digital camera. The molds are treated with boiling water which generates hydroxyl groups on the surface. Successful chemical modification of the polymer surface is confirmed using attenuated total reflection infrared (ATR-IR) analysis, and wettability is assessed through contact angle measurement. Postlab questions focus on the wettability of the physically and chemically modified surfaces and their potential use as scaffolding for tissue engineering. This adaptable experiment is designed to reinforce concepts such as intermolecular forces, introduce polymer structure and synthesis, showcase polymer applications in biological research, and provide an introduction to surface wettability in a visually interesting manner.

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Aqua-Art: A Demonstration of Hydrophilic and Hydrophobic Surfaces Fabricated by Plasma Enhanced Chemical Vapor Deposition

Cited by 13 publications

References 16 publications

Ultrasensitive and Reusable Graphene Oxide-Modified Double-Interdigitated Capacitive (DIDC) Sensing Chip for Detecting SARS-CoV-2

Ultrasensitive and Reusable Graphene Oxide-Modified Double-Interdigitated Capacitive (DIDC) Sensing Chip for Detecting SARS-CoV-2

An Electromagnetically Controllable Microrobotic Interventional System for Targeted, Real‐Time Cardiovascular Intervention

Effect of Chemical and Physical Modifications on the Wettability of Polydimethylsiloxane Surfaces

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