APTT therapeutic range for monitoring unfractionated heparin therapy. Significant impact of the anti‐Xa reagent used for correlation: Response from original authors Toulon et al.

Abstract

UFH treatments, because this point was evaluated neither in their article 2 nor in our studies. 1,5 Indeed, the key question raised by the reported lack of standardization of anti-Xa assays is how to accurately monitor UFH treatments, which is mandatory due to the high between-individual variability of the UFH anticoagulant activity and to its narrow therapeutic range, 3 as even the APTT therapeutic range calculated to correlate with anti-Xa activities between 0.30

Optimal volume for the draw-and-return methods to enhance activated partial thromboplastin time ratio accuracy in hemodialysis patients with central venous catheters

“…However, excessive usage of heparin can result in bleeding event, and its antithrombotic effect varies among patients, necessitating close monitoring in standard practice [ 5 , 6 ]. Heparin effect can be directly observed by using anti-activated factor X (anti-Xa) activity or activated partial thromboplastin time (aPTT) ratio which is more widely used and economically reasonable in our setting [ 7 , 8 ].…”