Aptasensor for electrochemical sensing of angiogenin based on electrode modified by cationic polyelectrolyte-functionalized graphene/gold nanoparticles composites

Graphene and Graphene‐Based Materials in Biomedical Science

“…Some of the compounds detected electrochemically using graphene and graphene‐based materials as electrode material include dopamine, glucose, H 2 O 2 , haemoglobin, DNA, glycoproteins, cancer cells, adenosine triphosphate (ATP), angiogenin, K562 leukemia cancer cells, human epidermal growth factor receptor 2; electrochemical DNA biosensor is developed for quantitative detection of breast cancer 1 (BRCA1) gene, impedimetric immunosensor for the direct detection of bacterial toxin botulinum has been developed using gold nanoparticles/graphene–chitosan composite, staphylococcal enterotoxin B has been detected using Au–Gr–Cs‐modified glassy carbon electrode, Au nanoparticles (NPs) nanocomposite and polypyrene electrochemically reduced graphene oxide flm‐coated disposable screen‐printed carbon electrode based on the voltammetric immunosensing method for fast, sensitive, and selective detection of two mycotoxins, deoxynivalenol, and fumonisin B1 (FB1) in spiked corn samples . Another impedimetric immunosensor has been developed for the rapid detection of ochratoxin (OTA) in food samples by immobilizing both anti‐OTA antibody and amine‐terminated dendrimer on the graphene oxide sheets .…”

Covalent attachment of aptamer onto nanocomposite as a high performance electrochemical sensing platform: Fabrication of an ultra-sensitive ibuprofen electrochemical aptasensor

“…Thus, using new transducers to enhance loading Apt onto the surface and to improve sensitivity is the recent trend in the fabrication of electrochemical aptasensors [20]. In the recent years, the combination of Apts with a variety of nanoengineered materials such as carbon nanotubes [21,22], graphene nanosheets [23], their nanocomposite [24,25], and noble metal nanoparticles [26][27][28] are shown for improving the performance of aptasensors. Also, these nanomaterial were applied for the development and fabrication of other biosensors.…”

Sensor detection in gynaecological medicine

“…The ability of this assay to work in real tissue samples bodes well for its use as an assay in human serum or blood samples. For angiogenin, an electrochemical sensor based on square wave voltammetry has been developed [223]. The sensor involved using anti-angiogenin bound to a gold electrode surface for measurements and was evaluated in human serum samples where it compared favorably to a standard ELISA assay.…”