Aptamer-functionalized fluorine-containing DNAsomes for targeted drug delivery to cancer cells

Fan, Shuhua; Liu, Xiaoyan; Yu, Shuxian; Wang, Juan; Li, Chuan; Cheng, Shuang; Hong, Maochun

doi:10.1039/d2nj00967f

New J. Chem.

2022

DOI: 10.1039/d2nj00967f

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Aptamer-functionalized fluorine-containing DNAsomes for targeted drug delivery to cancer cells

Shuhua Fan

Xiaoyan Liu

Shuxian Yu

et al.

Abstract: Due to the unique hydrophobic and lipophobic physicochemical properties of hydrophobic perfluorocarbons (PFs), here we report a conjugate of a double fluorine-containing lipid and oligonucleotide that can self-assemble into a...

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2024

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Fluorocarbon‐DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano‐Assembly

Narita,

Kohata,

Kageyama

et al. 2024

ChemBioChem

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Forming nano‐assemblies is essential for delivering DNA conjugates into cells, with the DNA density in the nano‐assembly playing an important role in determining the uptake efficiency. In this study, we developed a strategy for the facile synthesis of DNA strands bearing perfluoroalkyl (RF) groups (RF‐DNA conjugates) and investigated how they affect cellular uptake. An RF‐DNA conjugate bearing a long RF group at the DNA terminus forms a nano‐assembly with a high DNA density, which results in greatly enhanced cellular uptake. The uptake mechanism is mediated by clathrin‐dependent endocytosis. The use of RF groups to densely assemble negatively charged DNA is a useful strategy for designing drug delivery carriers.

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Fluorocarbon‐DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano‐Assembly

Narita,

Kohata,

Kageyama

et al. 2024

ChemBioChem

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show abstract

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Aptamer-functionalized fluorine-containing DNAsomes for targeted drug delivery to cancer cells

Abstract: Due to the unique hydrophobic and lipophobic physicochemical properties of hydrophobic perfluorocarbons (PFs), here we report a conjugate of a double fluorine-containing lipid and oligonucleotide that can self-assemble into a...

Cited by 1 publication

References 35 publications

Fluorocarbon‐DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano‐Assembly

Fluorocarbon‐DNA Conjugates for Enhanced Cellular Delivery: Formation of a Densely Packed DNA Nano‐Assembly

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