Aptamer-functionalized Au nanoparticles array as the effective SERS biosensor for label-free detection of interleukin-6 in serum

Muhammad, Muhammad; Shao, Changsheng; Huang, Qing

doi:10.1016/j.snb.2021.129607

Cited by 62 publications

(36 citation statements)

References 64 publications

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“…A high EF SERS was reported by Muhammad et al, [130] who devised a label-free SERS-based aptasensors for detecting interleukin-6 (IL-6) in mice serum in the range 1 × 10 −15 m-100 × 10 −12 m with an LOD of 0.8 × 10 −15 m (Figure 9e-1). The SERS substrate consisted of 44 nm diameter AuNPs homogenously distributed onto hexagonal nanopores rims of 53 nm diameter (Figure 9e-2).…”

Section: Sers-based Biosensingmentioning

confidence: 78%

“…Adapted with permission. [130] Copyright 2021, Elsevier B.V. f-1) Sketch of a silica-encapsulated hollow Au nanosphere (left panel) and TEM image of these core-shell nanoparticle in solution (right panel), f-2) scheme of the Au-patterned microarray chips, f-3) schematic representation of the detection scheme, and f-4) calibration curve obtained by measuring the SERS signal at 1650 cm −1 for the detection of vascular endothelial growth factor angiogenesis protein markers. Adapted with permission.…”

Section: Sers-based Biosensingmentioning

confidence: 99%

“…e-1) Scheme of the SERS substrate before (left panel) and after (right panel) the functionalization with probe aptamers, e-2) SEM image of AuNPs homogenously distributed onto the hexagonal nanopore rims, e-3) calibration curve for the detection of IL-6 in mice serum. Adapted with permission [130]. Copyright 2021, Elsevier B.V. f-1) Sketch of a silica-encapsulated hollow Au nanosphere (left panel) and TEM image of these core-shell nanoparticle in solution (right panel), f-2) scheme of the Au-patterned microarray chips, f-3) schematic representation of the detection scheme, and f-4) calibration curve obtained by measuring the SERS signal at 1650 cm −1 for the detection of vascular endothelial growth factor angiogenesis protein markers.…”

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confidence: 99%

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Nanostructured Surfaces as Plasmonic Biosensors: A Review

Minopoli

Acunzo

Ventura

et al. 2021

Adv Materials Inter

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are the main features exhibited by metal nanostructures thereby opening up the possibility for manipulating light at nanometric scale, well below the diffraction limit. [1] So far, the tremendous potentialities of the plasmon-related effects have been already represented a breakthrough in many application fields such as cancer treatment, [2] ultrasensitive molecule detection, [3] integrated circuitry, [4] quantum optics, [5] optoelectronics, [6] photovoltaics. [7] Several types of plasmonic nanostructures are being conceived these days aiming at improving the performance of plasmon-based devices. [8,9] At the basis of the nonpropagating plasmon phenomena there is the localized surface plasmon resonance (LSPR), namely, the collective oscillation of the conduction electron cloud against the metal core. [10] The plasmonic properties of metal nanomaterials strongly depend on the nanostructure geometry, arrangement, and environment. For instance, exotic nanostructures such as nanocages, nanoscaffolds, and bow-tie nanoantennas exhibit higher field enhancement than conventional nanoparticles with smooth surfaces thereby representing a considerable advantage in applications relying on signal amplification such as surface-enhanced Raman spectroscopy (SERS), [11,12] surface-enhanced infrared absorption (SEIRA), [13,14] and plasmon-enhanced fluorescence (PEF). [15,16] In addition, when nanostructures are ordered in periodic arrays, new modes can arise as a result of the near-or far-field coupling among the localized plasmons so as to activate hybrid effects such as coupled LSPR (c-LSPR) [17,18] and surface lattice resonance (SLR), [19][20][21] respectively. Besides, plasmonic properties offered by metamaterials were recently investigated and sparked considerable interest since they demonstrated to offer significantly better performance as compared to metal-based nanostructures in many fields of applications such as biosensing, [22] photonics, [23] photovoltaics, [24] and optoelectronics. [25] Nevertheless, the actual implications are still far-reaching for many scientific and engineering fields due to their complexity and low awareness. [25] Therefore, the possibility to tune the optical response of a nanostructure by tailoring the material, shape, and size, as well as the pattern architecture, is spurring the researchers to explore new approaches, in terms of both nanofabrication and nanoapplications, in order to go beyond the current limits of many techniques.The aim of the present work is to provide a comprehension of this growing field of research and to convey the main features of the nanostructured surfaces to biosensing applications.Conventional laboratory techniques exhibit impressive sensing performance and still constitute an irreplaceable tool in bioanalytics. Nevertheless, high costs, time consumption, and need for well-equipped laboratories and skilled personnel make highly desirable to explore novel strategies to carry out biochemical analyses. In this regard, biosensor-based methods represent a promising appr...

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Section: Sers-based Biosensingmentioning

confidence: 78%

Section: Sers-based Biosensingmentioning

confidence: 99%

mentioning

confidence: 99%

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Nanostructured Surfaces as Plasmonic Biosensors: A Review

Minopoli

Acunzo

Ventura

et al. 2021

Adv Materials Inter

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“…Upon recognition of IL-6 in serum, the aptamer altered its structure, resulting in a corresponding change in the output Raman intensity ratio, thus allowing for quantitative evaluation. The detection limit was 0.8 pM, suggesting that the aptamer-based SERS biosensor is a promising tool for fast and convenient medical diagnostic applications [63] (Figure 5f).…”

Section: Sersmentioning

confidence: 99%

Recent Advances in Aptasensor for Cytokine Detection: A Review

Kim

Noh

Park

et al. 2021

Sensors

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Cytokines are proteins secreted by immune cells. They promote cell signal transduction and are involved in cell replication, death, and recovery. Cytokines are immune modulators, but their excessive secretion causes uncontrolled inflammation that attacks normal cells. Considering the properties of cytokines, monitoring the secretion of cytokines in vivo is of great value for medical and biological research. In this review, we offer a report on recent studies for cytokine detection, especially studies on aptasensors using aptamers. Aptamers are single strand nucleic acids that form a stable three-dimensional structure and have been receiving attention due to various characteristics such as simple production methods, low molecular weight, and ease of modification while performing a physiological role similar to antibodies.

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“…The 10 −12 –10 −7 M range of IL-6 was successfully quantified. A biomedical application for the SERS-based aptamer biosensor has been demonstrated ( Muhammad et al, 2021 ). Figure 8 presents SERS based probe device of AuNPs for cancer detection.…”

Section: Aunps Based Optical Biosensing Of Cancer Proteinsmentioning

confidence: 99%

Gold Nanoparticles Based Optical Biosensors for Cancer Biomarker Proteins: A Review of the Current Practices

Tai

Fan

Ding

et al. 2022

Front. Bioeng. Biotechnol.

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Cancer prognosis depends on the early detection of the disease. Gold nanoparticles (AuNPs) have attracted much importance in biomedical research due to their distinctive optical properties. The AuNPs are easy to fabricate, biocompatible, surface controlled, stable, and have surface plasmonic properties. The AuNPs based optical biosensors can intensely improve the sensitivity, specificity, resolution, penetration depth, contrast, and speed of these devices. The key optical features of the AuNPs based biosensors include localized surface plasmon resonance (LSPR), SERS, and luminescence. AuNPs based biomarkers have the potential to sense the protein biomarkers at a low detection level. In this review, the fabrication techniques of the AuNPs have been reviewed. The optical biosensors based on LSPR, SERS, and luminescence are also evaluated. The application of these biosensors for cancer protein detection is discussed. Distinct examples of cancer research that have a substantial impact on both scientific and clinical research are presented.

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Aptamer-functionalized Au nanoparticles array as the effective SERS biosensor for label-free detection of interleukin-6 in serum

Cited by 62 publications

References 64 publications

Nanostructured Surfaces as Plasmonic Biosensors: A Review

Nanostructured Surfaces as Plasmonic Biosensors: A Review

Recent Advances in Aptasensor for Cytokine Detection: A Review

Gold Nanoparticles Based Optical Biosensors for Cancer Biomarker Proteins: A Review of the Current Practices

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