Aptamer-Enhanced Organic Electrolyte-Gated FET Biosensor for High-Specificity Detection of Cortisol

Massey, Roslyn S.; Bebe, Siziwe; Prakash, Ravi

doi:10.1109/lsens.2020.3002446

Cited by 24 publications

(19 citation statements)

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“…In terms of wearable biosensors, SOSs are ideal candidates for the active layers due to their signal amplification, molecular design capability, large‐area, low‐temperature solution processability, flexibility, and stretchability. [ 46,47,49,148 ] However, the operating voltages of OFETs are generally very high and most organic semiconductors are not stable when exposed to water. This makes them not compatible with biosensing in aqueous environments.…”

Section: Recent Progress In Wearable Electronics Based On Stretchable...mentioning

confidence: 99%

Wearable Electronics Based on Stretchable Organic Semiconductors

Zhao

Liu

2023

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Wearable electronics are attracting increasing interest due to the emerging Internet of Things (IoT). Compared to their inorganic counterparts, stretchable organic semiconductors (SOSs) are promising candidates for wearable electronics due to their excellent properties, including light weight, stretchability, dissolubility, compatibility with flexible substrates, easy tuning of electrical properties, low cost, and low temperature solution processability for large‐area printing. Considerable efforts have been dedicated to the fabrication of SOS‐based wearable electronics and their potential applications in various areas, including chemical sensors, organic light emitting diodes (OLEDs), organic photodiodes (OPDs), and organic photovoltaics (OPVs), have been demonstrated. In this review, some recent advances of SOS‐based wearable electronics based on the classification by device functionality and potential applications are presented. In addition, a conclusion and potential challenges for further development of SOS‐based wearable electronics are also discussed.

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Section: Recent Progress In Wearable Electronics Based On Stretchable...mentioning

confidence: 99%

Wearable Electronics Based on Stretchable Organic Semiconductors

Zhao

Liu

2023

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“…Massey et al prepared a non-invasive body fluid sensor based on EG-FET to monitor the cortisol hormone concentration in saliva samples. The detectable cortisol concentration range is currently identified as 27.3 pM–27.3 μM [ 246 ]. Shahub et al, on a nanoporous matrix by electrochemical impedance spectroscopy, measured cortisol concentrations in sweat with 100% accuracy and 0% false negatives, with a dynamic range of 8–140 ng/mL [ 247 ].…”

Section: Biochemical Signal Detectionmentioning

confidence: 99%

Recent Progress in Long-Term Sleep Monitoring Technology

Yin

Ren

2023

Biosensors

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Sleep is an essential physiological activity, accounting for about one-third of our lives, which significantly impacts our memory, mood, health, and children’s growth. Especially after the COVID-19 epidemic, sleep health issues have attracted more attention. In recent years, with the development of wearable electronic devices, there have been more and more studies, products, or solutions related to sleep monitoring. Many mature technologies, such as polysomnography, have been applied to clinical practice. However, it is urgent to develop wearable or non-contacting electronic devices suitable for household continuous sleep monitoring. This paper first introduces the basic knowledge of sleep and the significance of sleep monitoring. Then, according to the types of physiological signals monitored, this paper describes the research progress of bioelectrical signals, biomechanical signals, and biochemical signals used for sleep monitoring. However, it is not ideal to monitor the sleep quality for the whole night based on only one signal. Therefore, this paper reviews the research on multi-signal monitoring and introduces systematic sleep monitoring schemes. Finally, a conclusion and discussion of sleep monitoring are presented to propose potential future directions and prospects for sleep monitoring.

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“…The gate dielectric is commonly PBS [97]- [99] and the LOD can be as low as 1 pM [99]. A stacked dielectric EGFET device structure has been developed by Massey et al for the sensing of complex biofluids such as cortisol in saliva [100] without using PBS. They demonstrated the fabrication of a TGBC structure where the PMMA, Teflon coating, and cortisol aptamer-functionalized biofilm stack can be considered as the gate dielectric.…”

Section: B Cortisol Biosensingmentioning

confidence: 99%

Electrolyte-Gated Field Effect Transistors in Biological Sensing: A Survey of Electrolytes

Wang

Lian

Chu

2021

IEEE J. Electron Devices Soc.

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Low operating voltages, rapid response, and high-throughput fabrication compatibility are key advantages for the development of electrolyte-gated field effect transistors (EGFETs) for biological sensing. Among the key components in EGFET biosensors, electrolyte materials are relatively less investigated, especially alternatives to water-based liquid electrolytes such as ionic liquids, ion gels, polyelectrolytes, and solid polymer electrolytes. These electrolytes enable portable devices and environmental stability superior to their water-based liquid alternatives. In this review, we offer an up-to-date evaluation of the state of EGFET research and gauge the strengths and limitations of high-performance electrolytes for use in EGFET biosensor applications as well as the potential for computer-aided design of such sensing platforms. The recent progress of EGFET biosensors for some popular analytes are reviewed and the performance of these alternative electrolytes in transistor biosensing is assessed. The challenges and opportunities for electrolytes in EGFETs are discussed for future research directions in this field.

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Aptamer-Enhanced Organic Electrolyte-Gated FET Biosensor for High-Specificity Detection of Cortisol

Cited by 24 publications

References 0 publications

Wearable Electronics Based on Stretchable Organic Semiconductors

Wearable Electronics Based on Stretchable Organic Semiconductors

Recent Progress in Long-Term Sleep Monitoring Technology

Electrolyte-Gated Field Effect Transistors in Biological Sensing: A Survey of Electrolytes

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