Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas

Anti‐MUC1 aptamer: A potential opportunity for cancer treatment

“…By contrast, no cytotoxicity differences were observed in MUC1‐cell exposed to targeted or nontargeted NPs ( P > 0.05). Confocal fluorescence scanning microscopy also showed a more efficient uptake of APT‐HACSNPs than HACSNPs alone by HT‐29 cells . Notably, the protein corona could affect the biological identity of the MUC1 APT–HACSNPs, as coverage of the NPs with FBS proteins significantly increased HT29 cell viability in the presence of APT–NPs when compared to NPs alone, while no significant difference was observed in CHO cell viability.…”

Label-free fluorimetric detection of CEA using carbon dots derived from tomato juice

“…In addition, aptamers generally exhibit high specificity and affinity for their targets, and their structural flexibility allows for adaptation of undergoing significant conformational changes once aptamers and their targets specifically bind with each other (Blind and Blank, 2015;Nielsen et al, 2010). Hence, these attractive superiorities potentiate them as ideal biosensing molecules (Billinge et al, 2014;Kim et al, 2015;Ara et al, 2014;Song et al, 2014), and aptamer have been exploited in biorecognition applications of proteins, cancer cells and cancer medicine Xiang et al, 2015;Ghasemi et al, 2015;Kim and Gu, 2014). Currently, various types of nanomaterials have been employed to provide fluorescence response and construct ultrasensitive biosensors with the development of nanoscience and nanotechnology (Min et al, 2011;Zhang, 2012).…”

Silk fibroin nanoparticle as a novel drug delivery system

“…In recent years, in order to optimize the efficacy of therapeutics, many drug delivery systems have been designed to administer multiple drugs and release them in a controlled manner [1][2][3][4]. The use of these systems offers many advantages such as enhancing the bioavailability of drugs by reducing their degradation rate, improving cellular uptake, allowing targeting and control of drug release, and reducing side effects [5].…”