Aptamer-Conjugated Graphene Quantum Dots/Porphyrin Derivative Theranostic Agent for Intracellular Cancer-Related MicroRNA Detection and Fluorescence-Guided Photothermal/Photodynamic Synergetic Therapy

Cao, Yu; Dong, Haifeng; Yang, Zhou; Zhong, Xiangmin; Chen, Yi; Dai, Wenhao; Zhang, Xueji

doi:10.1021/acsami.6b13150

Cited by 186 publications

(149 citation statements)

References 44 publications

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“…Xiu et al studied the interactions between Ag NPs and bacterial cells (Figure 6). [77,82] Cu NPs that were incorporated into starch hydrogels [81] and functional polymer coatings [87] were found to display broad-spectrum antimicrobial activity. Ag NPs with different coatings and sizes under aerobic conditions were found to release Ag + , resulting in significant bacteria reduction.…”

Section: Metal Nps As Antibacterial Agents Due To Releasing Metal Ionsmentioning

confidence: 99%

Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection

Yuan

Ding

Yang

et al. 2018

Adv Healthcare Materials

153

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Infectious diseases caused by pathogenic bacteria, especially multidrug‐resistant bacteria, and their global spreading have become serious public health concerns. Early diagnosis and effective therapy can efficiently prevent deterioration and further spreading of the infections. There is an urgent need for sensitive, selective, and facile diagnosis as well as therapeutically potent treatment. The emergence of nanotechnology has provided more options for diagnosis and treatments of bacterial infections. Metal nanoparticles and metal oxide nanoparticles have drawn intense attention owing to their unique optical, magnetic, and electrical properties. These versatile metal‐based nanoparticles have great potential for selective detection of bacteria and/or therapy. This review gives an overview of recent efforts on developing various metal‐based nanoparticles for bacterial detection and infection therapy. It begins with an introduction of fundamental concepts and mechanisms in designing diagnostic and therapeutic strategies. Representative achievements are selected to illustrate the proof‐of‐concept in vitro and in vivo applications. A brief discussion of challenges and perspective outlook in this field is provided at the end of this review.

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Section: Metal Nps As Antibacterial Agents Due To Releasing Metal Ionsmentioning

confidence: 99%

Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection

Yuan

Ding

Yang

et al. 2018

Adv Healthcare Materials

153

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“…Compared with the above‐described monofunctional miRNA sensor, a fascinating multifunctional theranostic platform that coupled diagnostic and therapeutic functions and held great promise for personalized nanomedicine was fabricated by Cao and co‐workers . In this study, a porphyrin (P) derivative with high singlet oxygen generation ability and graphene GQDs possessing good fluorescence properties were synthesized.…”

Section: State‐of‐the‐art Protocols For High‐quality Mirna Detectionmentioning

confidence: 99%

“…B) Schematic presentation of GO‐PEG‐P theranostic platform for intracellular miRNA detection and combined photothermal/photodynamic therapy. Reproduced with permission . Copyright 2016, American Chemical Society.…”

Section: State‐of‐the‐art Protocols For High‐quality Mirna Detectionmentioning

confidence: 99%

Progress in miRNA Detection Using Graphene Material–Based Biosensors

Zhang

Miao

Sun

et al. 2019

Small

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MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that play critical roles in physiologic and pathologic processes and are vital biomarkers for several disease diagnostics and therapeutics. Therefore, rapid, low‐cost, sensitive, and selective detection of miRNAs is of paramount importance and has aroused increasing attention in the field of medical research. Among the various reported miRNA sensors, devices based on graphene and its derivatives, which form functional supramolecular nanoassemblies of π‐conjugated molecules, have been revealed to have great potential due to their extraordinary electrical, chemical, optical, mechanical, and structural properties. This Review critically and comprehensively summarizes the recent progress in miRNA detection based on graphene and its derivative materials, with an emphasis on i) the underlying working principles of these types of sensors, and the unique roles and advantages of graphene materials; ii) state‐of‐the‐art protocols recently developed for high‐performance miRNA sensing, including representative examples; and iii) perspectives and current challenges for graphene sensors. This Review intends to provide readers with a deep understanding of the design and future of miRNA detection devices.

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“…24,25 Such accumulation not only enhances tumor imaging and PDT efficacy but also helps minimize phototoxic damage to normal tissues in PDT. 26,27 The mitochondrion, an ideal hypersensitive organelle, generates reactive oxygen species (ROS) and regulates apoptosis. [28][29][30] If the ROS is generated by PDT in the mitochondrion, the adjacent biomolecules are damaged directly and efficiently, activating the cell apoptosis signaling pathway and accelerating cell death.…”

Section: Introductionmentioning

confidence: 99%