Aptamer-based radiopharmaceutical for PET/CT detection of lung cancer

Abstract

The paper describes a new radiopharmaceutical for diagnosis of lung cancer obtained on the basis of a radiolabeled 11C oligonucleotide and the study of its effectiveness in-vivo. As a result of the synthesis, an aptamer to lung cancer containing 11С in the 3'-position was obtained and remained stable for 60 minutes. Prior to xenotransplantation of human lung cancer cells, the mice were immunosuppressed. Tumour volumes and locations were monitored using PET/CT. The study of accumulation of the radiopharmaceutical in the organs of mice in vivo has shown that the 11C-labeled lung cancer aptamer specifically binds to lung cancer cells. A radiopharmaceutical based on 11C-labeled LC aptamer against lung cancer is a promising drug for lung cancer diagnosing