Abstract:The paper describes a new radiopharmaceutical for diagnosis of lung cancer obtained on the basis of a radiolabeled 11C oligonucleotide and the study of its effectiveness in-vivo. As a result of the synthesis, an aptamer to lung cancer containing 11С in the 3'-position was obtained and remained stable for 60 minutes. Prior to xenotransplantation of human lung cancer cells, the mice were immunosuppressed. Tumour volumes and locations were monitored using PET/CT. The study of accumulation of the radiopharmaceutic… Show more
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