2012
DOI: 10.1371/journal.pone.0048817
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Apricot Melanoidins Prevent Oxidative Endothelial Cell Death by Counteracting Mitochondrial Oxidation and Membrane Depolarization

Abstract: The cardiovascular benefits associated with diets rich in fruit and vegetables are thought to be due to phytochemicals contained in fresh plant material. However, whether processed plant foods provide the same benefits as unprocessed ones is an open question. Melanoidins from heat-processed apricots were isolated and their presence confirmed by colorimetric analysis and browning index. Oxidative injury of endothelial cells (ECs) is the key step for the onset and progression of cardiovascular diseases (CVD), th… Show more

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Cited by 51 publications
(45 citation statements)
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“…The 24 h of incubation. After mixing, 2.5 mL of 10% ethanol were added, the absorbance was measured at 232 nm and the percentage of antioxidant activity was calculated by the equation 3 with slight modifications [20] .…”
Section: Lipid Oxidation Inhibition Assaymentioning
confidence: 99%
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“…The 24 h of incubation. After mixing, 2.5 mL of 10% ethanol were added, the absorbance was measured at 232 nm and the percentage of antioxidant activity was calculated by the equation 3 with slight modifications [20] .…”
Section: Lipid Oxidation Inhibition Assaymentioning
confidence: 99%
“…( ΔODcont -ΔODextr ) % LOI= 伊100 ΔODcont (3) Where ΔODcont is the difference between 24 and 1 h of lipid oxidation in controls and ΔODextr is the difference between 24 and 1 h of lipid oxidation in samples.…”
Section: Lipid Oxidation Inhibition Assaymentioning
confidence: 99%
See 1 more Smart Citation
“…The unique cationic dye JC-1 (5, 5′6, 6′-tetrachloro-1, 1′3, 3′-tetraethylbenzimidazolylcarbocyanine iodide) was used to signal the loss of mitochondrial membrane potential [33]. Cancer cell lines were exposed to JY-1-106 at 5 μM for 12 hours.…”
Section: Methodsmentioning
confidence: 99%
“…Melanoidin is generally known as a nonenzymatic browning product obtained by the Maillard reaction . Melanoidin is a heterogeneous polymer that is relatively hydrophilic and negatively charged.…”
Section: Photonic Nanomaterialsmentioning
confidence: 99%