Aprepitant: A substance P antagonist for chemotherapy induced nausea and vomiting

Girish, Chandrashekaran; Manikandan, S.

doi:10.4103/0019-509x.31164

Cited by 34 publications

(22 citation statements)

References 15 publications

(20 reference statements)

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“…ImageJ is a public domain Java image processing program inspired by NIH Image for the Macintosh. The author, Wayne Rasband is at the Research Services Branch, National Institute of Mental Health, Bethesda, Maryland, USA [14][15][16]. ImageJ holds a unique position because it is not only in the public domain, but also runs on any operating system.…”

Section: Analysis Methodsmentioning

confidence: 99%

A New Procedure for Porous Material Characterization

Chilev¹

2017

IJSTS

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Abstract:A new procedure for quantitative characterization of different types of solid materials is proposed. The technique is based on the Scanning Electron Microscopy (SEM) analysis results of porous materials and their processing by the software ImageJ. Several types of porous adsorbents AX21, AC35, GAC250, ACENO and IRH3 activated carbons were investigated. Based on SEM analysis, different characteristics of the samples such as porosity, pore size distribution, bed particles porosity can be obtained. In this study, the particle size, the average macropore size and pore size distributions (PSD) of samples were determined with a new procedure for SEM analysis treatment using ImageJ software. Three distribution functions (Gamma, Weibull and Lognormal) were selected to describe the experimental results. The Lognormal distribution fitted more accurately the experimental data.

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Section: Analysis Methodsmentioning

confidence: 99%

A New Procedure for Porous Material Characterization

Chilev¹

2017

IJSTS

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“…Metabolization of aprepitant is carried out primarily by CYP3A4 and minor metabolism by CYP1A2 and CYP2C19. The half-life ranged from 9 to 13 hours approximately 5,17,18 .…”

Section: Recent Advances In Antiemeticsmentioning

confidence: 99%

“…Its potential emetic effects result from binding to the NK1 receptor. Substance P levels in the peripheral circulation may become elevated after administration of cisplatin 4,5,6 . (ii) abdominal vagus by means of the nucleus tractus solitarius.…”

Section: Pathophysiology Of Emesismentioning

confidence: 99%

Untitled

2013

IJPSR

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The act of emesis is controlled by the vomiting centre in the medulla, which integrates afferent input from the vestibular system, the chemoreceptor trigger zone (CTZ), the cortex and the gut. Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanism of action of antiemetic is related to blockage of various type of receptor located in various region of various organ of the body parts. Various drugs are classified under antiemetic like Ondansetron, Granisetron & Metochlopramide etc. A critical review of the studies of aprepitant (a new NK1 receptor antagonist) and of palonosetron (a 5-HT3 receptor antagonist with a longer half-life) presented in this article. Aprepitant combined with dexamethasone and a 5-HT3 antagonist significantly increase the control of acute emesis with respect to dexamethasone. Palonosetron showed superior or similar efficacy to Ondansetron and dolasetron in patients submitted to moderately emetogenic chemotherapy Certain side effects arise due to excessive use of antiemetic like twitching, flushing of skin, headaches, tiredness, indigestion etc. INTRODUCTION:

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“…Drugs which block substance P from binding to neurokinin type 1 (NK1) receptors can be of use as antiemetic agents as these neurotransmitters are implicated in the pathoetiology of emesis [3,4] Fig. 1), is a new class of substance P/Neurokinin1 (NK1) receptor antagonist, which is effective on both acute and delayed emesis.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green as Chromogenic Reagent

Souri¹,

Abbasi²,

Amanlou³

et al. 2018

Asian J. Chem.

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Aprepitant is a substance P/neurokinin 1 receptor antagonist, which is used for preventing both acute and delayed emesis. In the present study a simple and accurate spectrophotometric method has been developed for quantitative determination of aprepitant in bulk and pharmaceutical dosage forms based on the formation of ion-pair complex between the drug and bromocresol green. The 1:1 yellow colour aprepitant-bromocresol green (BCG) ion-pair complex was formed in buffer solution at pH = 4, extracted with chloroform and measured at 413 nm. The optimum reaction conditions such as pH, reagent amount, extracting solvent and stoichiometry of the ion-pair complex were investigated. The developed method showed excellent linearity over the concentration range of 150-500 µg/mL with acceptable correlation coefficient (r 2 = 0.998), precision (CV < 3.67 %) and accuracy (Error < 3.46 %). The proposed method was successfully applied for determination of aprepitant in capsule dosage forms and no interference from excipients was observed.

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Aprepitant: A substance P antagonist for chemotherapy induced nausea and vomiting

Cited by 34 publications

References 15 publications

A New Procedure for Porous Material Characterization

A New Procedure for Porous Material Characterization

Untitled

Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green as Chromogenic Reagent

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