Appropriateness of choice and duration of surgical antibiotic prophylaxis and the incidence of surgical site infections: A prospective study

Thabit, Abrar K.; Fairaq, Ebtihal M.; Almutairi, Fahdah

doi:10.1016/j.jtumed.2022.08.012

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…According to hospital guidelines, the antibiotic choices were either first-generation (cefazolin) or second-generation (cefuroxime) cephalosporins, as they are more effective and have a narrower spectrum for infection-causing bacteria in these procedures. In our study, SAP choice was inappropriate in 15%, with non-compliance due to administering penicillins (combined with beta- In a similar study by Sefah IA et al [19] in Ghana, Thabit AK et al [20], and Piri A et al [21] in Western Iran, reasonable compliance (67.0%, 71.4%, 92.1%) with the choice of SAP to standard treatment guidelines was observed. In contrast to our study, a higher rate of inappropriateness in the selection of antibiotics for prophylaxis was observed in a study conducted in Islamabad, Pakistan by Khan Z et al [22], where compliance was only 4.2%.…”

Section: Discussionsupporting

confidence: 52%

Appropriateness of Surgical Antimicrobial Prophylaxis in a tertiary care hospital: A prospective observational study

L S

et al. 2023

Int. J. Res. Pharm. Sci.

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Surgical site infections (SSIs) are a significant concern in global healthcare, particularly in middle and low-income countries, leading to increased hospitalizations, morbidity, mortality, and financial strain. Ranked third in the CDC's National Nosocomial Infections Surveillance System, SSIs have prompted a focus on preventive measures, notably surgical antimicrobial prophylaxis (SAP). However, SAP is often used inappropriately, contributing to the rise of Antimicrobial Resistance (AMR). Addressing this, a six-month prospective observational study was conducted in a tertiary care hospital to assess the adherence to SAP guidelines among 386 patients undergoing surgeries in various specialties. The study aimed to evaluate the appropriateness of SAP practices and identify factors leading to non-compliance. Results showed that only 58.3% of patients fully adhered to the guidelines. While 100% compliance was observed in SAP indication, lower adherence was noted in the timing of administration (97.7%), choice of SAP (85%), and duration of prophylaxis (70.2%). These findings underscore a significant gap between recommended SAP practices and actual implementation. This gap highlights the need for stronger Institutional Antimicrobial Stewardship (AMS) programs and the critical role of clinical pharmacists in regularly evaluating SAP and prescribing practices. To combat the rise of antibiotic resistance while ensuring patient safety, enhancing SAP practices in line with national and international recommendations is essential. The study advocates for more active interventions at the time of order to optimize antibiotic use, thereby addressing the challenge of compliance in SAP guidelines.

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Section: Discussionsupporting

confidence: 52%

Appropriateness of Surgical Antimicrobial Prophylaxis in a tertiary care hospital: A prospective observational study

L S

et al. 2023

Int. J. Res. Pharm. Sci.

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“…3 Antibiotic selection is influenced by the organism most commonly causing wound infection in the specific procedure and by the relative costs of available agents. 4 Parenterally administered empirical antimicrobial for surgical inpatients is as high as 98% in Low and Middle Income Countries (LMIC). 5 Despite the introduction of National Antibiotic Treatment Guidelines (NATG) 6 in 2014, there is still a great deal of variation in SAP administration by various surgical teams and specialties, which may have an impact on adverse events and the emergence of antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Prophylaxis in Surgery: A Cross-Sectional Study in the Surgical Ward of a Tertiary Care Centre in Central Nepal

Karki,

Shrestha,

Yadav

et al. 2023

JCMC

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Background: Surgical Antimicrobial Prophylaxis is administration of a short course of antimicrobial agent prior to surgery. It has long been recommended for routine use in preventing occurrence of surgical site infections. The choice of drug, dosage, route, duration and timing of antimicrobial prophylaxis has been specified in the clinical practice guideline issued by American Society of Health-System Pharmacists. In the present study, we aim to seek the practice of antibiotic prophylaxis at a tertiary care centre in central Nepal and report the adherence to American and National Antimicrobial Treatment Guideline where applicable. Methods: This hospital-based cross-sectional study was conducted between January to June 2023 among 232 patients undergoing surgery at Chitwan Medical College Teaching Hospital. Data collection tool prepared with slight modification from previous studies recorded the demographic details, surgical data, surgical antimicrobial prophylaxis usage data and assessment of Prophylaxis data. Data analysis was done using SPSS-20. Results: We observed compliance to selection of drug, route of administration, dosage of antimicrobial prophylaxis with American guideline. All (100%) prophylaxis was administered parenterally for more than 72 hours in over 40% cases. Choice of drug was appropriate in over 84% of cases and dosage adequacy was observed in over 61% cases. Surgical antimicrobial prophylaxis was administered most frequently 30 minutes before surgery (52.59%). Conclusions: All the surgical patients were found to receive surgical antimicrobial prophylaxis. Ceftriaxone was the most commonly administered drug followed by combination of piperacillin and tazobactam. The duration of treatment post-surgery was found to be unnecessarily broader than recommended guideline.

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Appropriateness of choice and duration of surgical antibiotic prophylaxis and the incidence of surgical site infections: A prospective study

Cited by 2 publications

References 22 publications

Appropriateness of Surgical Antimicrobial Prophylaxis in a tertiary care hospital: A prospective observational study

Appropriateness of Surgical Antimicrobial Prophylaxis in a tertiary care hospital: A prospective observational study

Antimicrobial Prophylaxis in Surgery: A Cross-Sectional Study in the Surgical Ward of a Tertiary Care Centre in Central Nepal

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