Appropriateness of aminoglycoside prescriptions in a French university hospital

Muller, Allison; Leroy, J.; Patry, I.; Hénon, T.; Hocquet, Didier; Chirouze, Catherine; Bertrand, Xavier

doi:10.1016/j.medmal.2016.04.009

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…There is also evidence that an increase in the number of medications increases the probability of receiving a prescription for an antibiotic (Amaha et al, 2019). Finally, attacks classified as severe exposure were associated with a lower risk of inappropriate antibiotic use, a result that has also been shown in other clinical contexts (Muller et al, 2016; Osorio et al, 2020; Stuart et al, 2020). Muller et al (2016) and Osorio et al (2020) found that antibiotic prescriptions were adequate, especially when used for severe infections.…”

Section: Discussionsupporting

confidence: 73%

Use of antibiotics in patients who were attacked by animals that can transmit rabies

Valladales‐Restrepo

Vargas‐Díaz

Peña‐Verjan

et al. 2022

Zoonoses and Public Health

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Animal bites pose a major public health problem for children and adults worldwide (World Health Organization., 2018) and constitute up to 1% of all visits to emergency departments (Jaindl et al., 2016;Morzycki et al., 2019). The vast majority of bite injuries are caused by dogs and, to a lesser extent, by cats, monkeys, snakes and humans (Medeiros & Saconato, 2001;Williams et al., 2021). It has been estimated that the risk of being bitten by a domestic animal throughout life is approximately 50%, but only between 10% and 50% of injuries are reported to medical services (Pfortmueller et al., 2013).

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Section: Discussionsupporting

confidence: 73%

Use of antibiotics in patients who were attacked by animals that can transmit rabies

Valladales‐Restrepo

Vargas‐Díaz

Peña‐Verjan

et al. 2022

Zoonoses and Public Health

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“…These findings are consistent with the study by Muller A et al where aminoglycosides were mainly prescribed for the treatment of pulmonary infections, urinary tract infections, and febrile neutropenia and were always prescribed in combination with at least one other antibiotic from another class with a beta-lactam in 94% of cases. 12 The duration of antibiotic treatment needs to be individualized taking into account patient variables such as severity of illness, clinical response, and the type of infection. In view of the deleterious effects of prolonged courses of antimicrobial agents, including the potential for adverse reactions, selection of antibiotic-resistant organisms, and high cost, emphasis has been on shorter courses of therapy.…”

Section: Discussionmentioning

confidence: 99%

“…This is consistent with the findings from a study in a French university hospital and can be explained by the fact they were used mainly in children with conditions that resolved quickly such as respiratory distress syndrome as well as mild respiratory and urinary tract infections. 12 Vancomycin had the least duration because it was mainly used for prophylaxis against staphylococcal infections in patients undergoing dialysis.…”

Section: Discussionmentioning

confidence: 99%

Broad spectrum antibiotic use among in-patients at a hospital in Nairobi, Kenya

Mariita

Chirima

Maina³

2018

Int J Basic Clin Pharmacol

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Background: Antimicrobial resistance is an increasingly serious threat to global public health. While the use of antibiotics is an important contributing factor, there are gaps regarding this in our region. This study aimed to describe the use of nine broad spectrum antibiotics among in-patients of The Nairobi Hospital (TNH) so as to identify opportunities for quality improvement.Methods: This was a retrospective review of the use of meropenem, ertapenem, imipenem, cefepime, piperacillin, gentamicin, amikacin, vancomycin and teicoplanin among in-patients of TNH from 1st January 2018 to 31st March 2018. Demographic and clinical data of all in-patients who were prescribed these antibiotics during the study period were retrieved from patient files.Results: There were 301 study participants with a median age (range) of 30years (1day-74years), of whom 161 (53.5%) were male. More than half of the participants were admitted for less than one week and had at least one co-morbidity. Meropenem was the most commonly prescribed study antibiotic 123 (40.9%) followed by amikacin 89 (29.6%). Respiratory tract infections 125 (41.5%) were the predominant indications. Meropenem had the longest mean duration of administration, 6.5days while the aminoglycosides were administered for a relatively shorter duration of about 4.8days. Cultures were done on 187 (62.1%) patients though it is only samples of 45 patients that grew an organism, E. coli and Klebsiella sp being the most frequently isolated organisms.Conclusions: There’s a need to strongly intensify implementation of restriction strategies for Meropenem use and introduction of education programs on antimicrobial stewardship targeting all prescribers.

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