Background: Self-instructional-video is an effective self-directed learning method of clinical procedural skills. Method: A single-blinded randomized controlled study comparing small-group-learning and individuallearning was conducted to evaluate knowledge and skills retention of manual defibrillation and endotracheal intubation. Data were collected on knowledge, skill acquisition, and confidence, at pretest, post-test and retention at 6 months postintervention. Results: Small-group-learning demonstrated better outcomes on knowledge and skill acquisition of intubation compared to individual-learning. For defibrillation, both groups showed similar improvements in knowledge and skill acquisition. Conclusion: Self-directed small-group-learning is a better method for knowledge and skill acquisition, regardless of the procedure complexity.