Appropriate use of antibiotics for acute respiratory infections at primary healthcare facilities in China: a nationwide cross-sectional study from 2017 to 2019

Fu, Mengyuan; Gong, Zhiwen; Li, Can; Ling, Kexin; Zhu, Yuezhen; Li, Huangqianyu; Shi, Luwen; Guan, Xiaodong

doi:10.1016/j.lanwpc.2023.100880

Cited by 3 publications

(2 citation statements)

References 49 publications

(80 reference statements)

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“…In line with these observations, a study conducted by our colleagues revealed that diseases such as URTIs, acute bacterial otitis media, acute bacterial rhinosinusitis, and acute bacterial pharyngitis/tonsillitis were most commonly treated with broad–spectrum antibiotics instead of the narrow–spectrum ones recommended in the guidelines. 27 Additionally, another study by our colleagues found that prescription rate of quinolones for acute bronchitis in PHIs in China was approximately 7.2%, falling outside our target range of 20%–40%. 28 Therefore, the indicators indicating that over 90% of PHIs failed to meet the targets were consistent with findings from other studies.…”

Section: Discussionmentioning

confidence: 86%

Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator

Wushouer,

Yu,

et al. 2024

The Lancet Regional Health - Western Pacific

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Section: Discussionmentioning

confidence: 86%

Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator

Wushouer,

Yu,

et al. 2024

The Lancet Regional Health - Western Pacific

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“…Accurate prescriptions should be based on the AST results of the infecting pathogen, but standard AST takes days. Therefore, in practical terms, the demand for rapid clinical intervention often necessitates empirical drug prescriptions in the absence of AST data, posing the risk of ineffective treatment and AMR development [ 194 ]. Advanced molecular profiling methods, such as those discussed in Sect.…”

Section: Ai In Antimicrobial Developmentmentioning

confidence: 99%

Antimicrobial resistance crisis: could artificial intelligence be the solution?

Liu,

Yu,

Fan

et al. 2024

Military Med Res

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Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be developed. The discovery and introduction of novel antibiotics are time-consuming and expensive. According to WHO’s report of antibacterial agents in clinical development, only 18 novel antibiotics have been approved since 2014. Therefore, novel antibiotics are critically needed. Artificial intelligence (AI) has been rapidly applied to drug development since its recent technical breakthrough and has dramatically improved the efficiency of the discovery of novel antibiotics. Here, we first summarized recently marketed novel antibiotics, and antibiotic candidates in clinical development. In addition, we systematically reviewed the involvement of AI in antibacterial drug development and utilization, including small molecules, antimicrobial peptides, phage therapy, essential oils, as well as resistance mechanism prediction, and antibiotic stewardship.

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Study on General Practitioners' Cognition of Antibacterial Drugs Use

Liu,

Zheng,

Yang

et al. 2024

Preprint

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Background Rational use of antimicrobial drugs play an important role in improving clinical efficacy. However, inappropriate antibiotic use accelerates antimicrobial resistance, We aimed to assess the general practitioner's understanding of the use of antibiotics. Methods A self-designed online questionnaire was conducted among general practitioners. The content includes basic information, general practitioners' understanding of the use of antibiotics,training needs for general practitioners (GPs) on use of antibiotics. Results A total of 772 GPs participated in the survey,with an average age of 40.97±8.87 years, of which 46.63%(360) were male.724（93.78%）GPs agree“High rates of antibiotic use could lead to bacterial resistanc”.657（85.10%）GPs agree“A serious problem of antibiotic abuse in China”.711（92.10%）GPs agree “Abuse of antibiotics is one of the main reasons for bacterial resistance”.661(85.62%) GPs agree“Need fast and effective diagnostic techniques to assist me in using antibiotics”. 561(72.67%) GPs often promote rational medication knowledge to patients, 582(75.39%) GPs often study adverse reactions of drugs and inform to patients.496(64.25%) GPs often actively learn about antibacterial drug related knowledges, 424(54.92%) GPs often require clinical or laboratory evidence of bacterial infections when using antibiotics. On average, 247（32.05%） GPs master in the use of antibiotics, and 364（47.18%） GPs indicate that they are familiar with the use of antibiotics. On average, 627(81.21%) GPs have chosen appropriate answers regarding the use of antibiotics. 754(97.67%) GPs consider it was necessary to participate in training on the rational use of antibiotics, and 745(96.51) GPs have training needs. 713(92.36%) GPs believe that clinical pharmacist intervention is necessary when using antibiotics. Conclusions The rational application of antibiotics is the key to improving efficacy. Most GPs have a good understanding of when to use antibiotics and the plan for using antibiotics, but there are significant differences on some issues.More than 90% of GPs believe that training on antibiotics and intervention from clinical pharmacists are necessary. So, it is recommended to strengthen the training of general practitioners, based on evidence-based medicine, strictly grasp the indications for the use of antibiotics, strive for targeted treatment, reduce experiential treatment, and ensure that the indications, variety selection, administration route, dosage, and course of treatment for the use of antibiotics are suitable for patients.

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Appropriate use of antibiotics for acute respiratory infections at primary healthcare facilities in China: a nationwide cross-sectional study from 2017 to 2019

Cited by 3 publications

References 49 publications

Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator

Evaluation of appropriateness of antibiotic prescribing in primary healthcare institutions in China using proxy indicator

Antimicrobial resistance crisis: could artificial intelligence be the solution?

Study on General Practitioners' Cognition of Antibacterial Drugs Use

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