Appropriate Surgical Treatment of Symptomatic Primary Varicose Veins Decreases Systemic Inflammatory Biomarkers

Abstract

Objective: To evaluate the relationship between systemic inflammatory biomarkers and efficacy of surgical treatment of primary varicose veins of the lower extremities.Methods: Total 12 patients who underwent endovenous laser ablation or stripping of varicose veins and six healthy subjects were enrolled. Structural and molecular changes of varices were assessed by immunohistochemical staining with anti-monocyte chemotactic protein-1 (MCP-1). MCP-1 and interleukin-6 (IL-6) levels in systemic antecubital blood were measured before and at 12 weeks after treatment.Results: Immunohistochemical staining revealed prominent manifestation of MCP-1-positive endothelial cells in the walls of varices. Preoperative serum MCP-1 and IL-6 levels in the patients were significantly higher than those in the control (166±12 pg/mL vs 99±10 pg/mL, p=0.003; 5.1±0.95 pg/mL vs 0.0±0.0 pg/mL, p=0.001, respectively). The values were significantly correlated with the severity of chronic venous insufficiency (CVI). Postoperative serum MCP-1 level significantly decreased compared with the preoperative level (152±10 pg/mL vs 166±12 pg/mL, p=0.048). The values after endovenous laser ablation did not significantly decrease compared with those after stripping.Conclusion: Varicose veins with CVI increase inflammatory biomarker levels in the local tissue and systemic blood. Appropriate treatment of symptomatic varicose veins decreases inflammatory biomarker levels.

Molecular Determinants of Chronic Venous Disease: A Comprehensive Review

“…Sci. 2023, 24,1928 9 of 14 also some clinical studies that confirmed MCP-1 serum concentration changes after venous invasive procedures and also after venoactive drug treatment, and this may account for its role as an effective biomarker in CVD clinical management [107][108][109][110]. Figure 1 summarizes the main pathophysiological steps in CVD development that have been discussed so far in various sections of this article.…”

“…In this regard, a study showed a preventive effect on varicose vein development after MCP-1 expression suppression [106]. Moreover, there are also some clinical studies that confirmed MCP-1 serum concentration changes after venous invasive procedures and also after venoactive drug treatment, and this may account for its role as an effective biomarker in CVD clinical management [107][108][109][110].…”

Avaliação de marcadores séricos de inflamação, trombose e moléculas de adesão no tratamento da insuficiência da veia safena magna pelas técnicas cirúrgica convencional e termoablação por radiofrequência

“…No nosso estudo, curiosamente, evidenciamos uma diminuição do TAT tanto no pós-operatório dos casos de SFN quanto no de RFA em 30 dias. Alguns estudos relacionam a presença de varizes com estados inflamatórios ou pró-trombóticos elevados e, quando é feito o tratamento cirúrgico, ocorre uma diminuição desses fatores (ARASE, et al, 2019). Esta poderia ser, uma explicação deste comportamento inesperado do TAT.…”