Appropriate dosing of sugammadex and rocuronium for reversal of neuromuscular blockade and reparalysis

Oda, Yutaka

doi:10.1007/s00540-020-02842-3

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Body mass index of greater than 50 kg·m −2 is an independent predictor of both difficult intubation and face mask ventilation [ 34 ]. In case of RSI for an inadequate period of fasting or abdominal pathology (rocuronium 1.2 mg/kg), ideal body weight IBW for muscle relaxation followed by sugammadex 8–16 mg/kg actual body weight permit a better control of neuromuscular block in case of failed intubation [ 35 ]. This scenario requires enough sugammadex available on site before induction.…”

Section: Operating Room Emergenciesmentioning

confidence: 99%

Sugammadex in Emergency Situations

Motamed

2023

JPM

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Sugammadex may be required or used in multiple emergency situations. Moderate and high doses of this compound can be used inside and outside the operating room setting. In this communication, recent developments in the use of sugammadex for the immediate reversal of rocuronium-induced neuromuscular blockade were assessed. In emergency surgery and other clinical situations necessitating rapid sequence intubation, the tendency to use rocuronium followed by sugammadex instead of succinylcholine has been increasing. In other emergency situations such as anaphylactic shock caused by rocuronium or if intubation or ventilation is not possible, priority should be given to resuming ventilation maintaining hemodynamic stability, in accordance with the traditional guidelines. If necessary for the purpose of resuming ventilation, reversal of neuromuscular blockade should be done in a timely fashion.

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Section: Operating Room Emergenciesmentioning

confidence: 99%

Sugammadex in Emergency Situations

Motamed

2023

JPM

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Rapid sequence intubation and the role of the emergency medicine pharmacist: 2022 update

Hampton

Hommer

Musselman

et al. 2022

American Journal of Health-System Pharmacy

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Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose The dosing, potential adverse effects, and clinical outcomes of the most commonly utilized pharmacologic agents for rapid sequence intubation (RSI) are reviewed for the practicing emergency medicine pharmacist (EMP). Summary RSI is the process of establishing a safe, functional respiratory system in patients unable to effectively breathe on their own. Various medications are chosen to sedate and even paralyze the patient to facilitate an efficient endotracheal intubation. The mechanism of action and pharmacokinetic/pharmacodynamic profiles of these agents were described in a 2011 review. Since then, the role of the EMP as well as the published evidence regarding RSI agents, including dosing, adverse effects, and clinical outcomes, has grown. It is necessary for the practicing EMP to update previous practice patterns in order to continue to provide optimal patient care. Conclusion While the agents used in RSI have changed little, knowledge regarding optimal dosing, appropriate patient selection, and possible adverse effects continues to be gained. The EMP is a key member of the bedside care team and uniquely positioned to communicate this evolving data.

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Appropriate dosing of sugammadex and rocuronium for reversal of neuromuscular blockade and reparalysis

Cited by 2 publications

References 18 publications

Sugammadex in Emergency Situations

Sugammadex in Emergency Situations

Rapid sequence intubation and the role of the emergency medicine pharmacist: 2022 update

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