Approaches used in secondary prevention of eating disorders: review of the evidence and effectiveness

Roncero, Carlos; Ruiz-Lázaro, Pedro Manuel; Hornero, Jesús Pérez

doi:10.20960/nh.04185

Cited by 1 publication

(1 citation statement)

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“…Another acquired immune microvascular thrombotic condition, thrombotic thrombocytopenic purpura, the classical form or the recently described vaccine-induced form, is regularly described as sometimes accompanied by a psychiatric symptomatology, at diagnosis as well as in its evolution or aftereffects. 62 63 64 65…”

Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibodies in Mental Disorders

Gris,

Chéa,

Bouvier

et al. 2024

Semin Thromb Hemost

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Thrombotic events striking the central nervous system are clinical criteria for the antiphospholipid syndrome (APS). Besides these, neuropsychiatric non-APS criteria manifestations are increasingly described in patients with persistently positive antiphospholipid antibodies (aPL). Among these are psychiatric manifestations. Animal models mainly describe hyperactive behavior and anxiety associated with hippocampal abnormalities. Cases of associations with psychosis, mood disorders, bipolarity, anxiety, obsessive–compulsive behavior, and depression have been reported but are still rare. Systematic human clinical association studies are concordant with a risk of psychosis, depression (simple to major), and anxiety disorders, but these are limited and of inconstant methodological quality. Brain imaging in patients, also insufficiently investigated, shows early signs of hypoperfusion and of subtle diffuse white matter changes compatible with an alteration of the axonal structure and changes in the myelin sheath. Direct interactions of aPL with the brain cells, both on cell lines and on animal and human brain biopsies, targeting both glial cells, astrocytes, and neurons, can be demonstrated. These clusters of arguments make the association between psychiatric diseases and aPL increasingly plausible. However, a considerable amount of clinical research must still be performed in accordance with the highest standards of methodological quality. The therapeutic management of this association, in terms of both prevention and cure, currently remains unresolved.

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Section: Discussionmentioning

confidence: 99%