Approaches to the Search of the Optimum Packaging of Eye Drops

Abstract

The purpose of this study is to find a unique ophthalmic packaging that takes into account modern requirements for both maintaining the quality and safety of the drug, compliance with therapy, and increasing the profitability and environmental friendliness of its production. Statistics from open international databases on drugs approved for ophthalmic therapy in 2022 are provided. The research criteria were a valid registration status, the type of packaging and the presence of a preservative in the composition of the eye drops. The results of statistical processing of databases of ministries of health of different countries have shown the relevance of monodose ophthalmic packaging, capable of long-term storage of the drug without preservatives. In many countries, particularly in Europe, many drugs in the form of a monodose containers are registered. On this basis, a unique aluminum-based monodose container design is proposed, eliminating the use of large quantities of plastic.

Ocular Inserets as a Modern Therapy Trend in Opthalmopathology

“…The base preparation can be carried out in two ways: in the presence of a solvent by mixing the components or by hot melt extrusion, where a dry or slightly moistened mixture is forced through an extruder when heated. In the first case, the API and excipients are dissolved in a solvent in a reactor with a steam jacket (if temperature is required when using a certain API) and a propeller mixer (for example, Customized IVEN-3, IVEN, China) and then poured onto prepared substrates on tapes in drying oven (for example, SHSV-3000, NPF Thermokon, Russia, BINDER GmbH, Germany) until complete solidification, after which the OI is transferred to packaging lines [41]. Such a traditional manufacturing method has limitations for large-scale production when the production of inserts by extrusion allows continuous production of economical polymer inserts.…”

“…Synthetic thermoplastic polymers, such as polypropylene and its derivatives, can be selected by manufacturers as the main material. The advantage of polypropylene is its relatively low cost, the possibility of injection molding and autoclaving [41,45]. To reduce the risk of microbial contamination while administrating an applicator (tweezers with a rubber tip) equipped with an external packaging in the form of a plastic container for protection from contamination and storage after use (fig.…”