Approaches to the rational design of molecularly imprinted polymers

Davies, Michelle; Biasi, Vern de; Perrett, David

doi:10.1016/s0003-2670(03)00812-2

Cited by 96 publications

(58 citation statements)

References 20 publications

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“…More recently, several promising methods to approach the optimization problem in a more systematic way have been demonstrated. Chemometrical approaches, combinatorial synthesis, high-throughput screening, and computational methods have been applied to investigate factors of importance in the synthesis protocol and to expedite the optimization of polymer compositions towards high selective rebinding of the template [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Influence of salt ions on binding to molecularly imprinted polymers

Kempe

2009

Anal Bioanal Chem

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Section: Introductionmentioning

confidence: 99%

Influence of salt ions on binding to molecularly imprinted polymers

Kempe

2009

Anal Bioanal Chem

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“…The distribution coefficient K was utilized to evaluate the molecular selectivity of MIPs [21]. K is defined as follows:…”

Section: Binding Experimentsmentioning

confidence: 99%

“…The main disadvantages of this approach are that it needs high number of experiments and it does not consider any possible interaction between the studied variables. To overcome this shortcoming, multivariate optimization methods are considered as promising techniques which use experimental design in conjunction with multivariate analysis techniques to optimize different processes [19][20][21][22]. Zhu et al [19] investigated the influence of process parameters on the preparation of vinblastine-imprinted polymers.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, optimization, and characterization of molecularly imprinted nanoparticles

2013

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Nanoparticles of molecularly imprinted polymers (MIPs) were prepared by precipitation polymerization method. Glucose was used as a template molecule. The impact of different process parameters on the preparation of nanoparticles was investigated in order to reach the maximum binding capacity of MIPs. Experimental data based on uniform design were analyzed using artificial neural network to find the optimal condition. The results showed that the binding ability of nanoparticles of MIPs prepared under optimum condition was much higher than that of the corresponding non-imprinted nanoparticles (NIPs). The findings also demonstrated high glucose selectivity of imprinted nanoparticles. The results exhibited that the particle size for MIP nanoparticles was about 557.6 nm, and the Brunauer-Emmett-Teller analysis also confirmed that the particle pores were mesopores and macropores around 40 nm and possessed higher volume, surface area, and uniform size compared to the corresponding NIPs.

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“…The template must remain stable under the reaction conditions. Any change in conformation of the template could lead to incorrectly formed imprinted sites [18]. If a thermal initiation is chosen, the template should not degrade under the temperatures of polymerization.…”

Section: Introductionmentioning

confidence: 99%

Polyacrylamide gels with selective recognition of the tetrameric molecular form of human growth hormone

Kublickas¹,

Werner²,

Voit³

2017

Express Polym. Lett.

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Abstract. Networks of polyacrylamide were studied for the possibility of imprinting of the oligomeric form of human growth hormone. The tetrameric molecular form of human growth hormone was molecularly imprinted for the first time. The results show that approximately 50-70% (w/w) of the templates (depending on polymerization conditions) could be extracted from the molecularly imprinted acrylamide polymers. The resulting 'gel antibodies' against this form of human growth hormone in the form of granules of polyacrylamide were compared with granules of non-imprinted polymer. The selectivity of the artificial gel antibodies was studied. Investigation of the binding to imprinted polymer of the template hormone, other molecular forms of the hormone and other proteins shows the selectivity of the developed artificial gel antibodies.

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Approaches to the rational design of molecularly imprinted polymers

Cited by 96 publications

References 20 publications

Influence of salt ions on binding to molecularly imprinted polymers

Influence of salt ions on binding to molecularly imprinted polymers

Synthesis, optimization, and characterization of molecularly imprinted nanoparticles

Polyacrylamide gels with selective recognition of the tetrameric molecular form of human growth hormone

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