Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.034 View full text
C. Ortiz-Bolsico, J.R. Torres-Lapasió, M.C. García-Álvarez-Coque

Abstract: Chromatographic problems are usually addressed trying to find out a single experimental condition aimed to resolve all compounds in the sample. However, very often, the chromatographic system is not able to provide full resolution. When a separation fails, the usual choice is introducing a drastic change in the chromatographic system (e.g. column, solvent, pH). There are, however, other possibilities that take advantage of the gathered information in the failed separation, without the need of new experiments, …

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