Approaches for encephalic drug delivery using nanomaterials: The current status

Anoop,; Cutinho, Linda Ilene; Mourya, Paladugu; Maxwell, Amala; Thomas, Githa; Rajput, Brijesh Singh

doi:10.1016/j.brainresbull.2019.11.017

Cited by 18 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BBB strictly limits the transcellular movement of drugs and nanoparticles from blood to brain (Gao, 2016 ). Macromolecules, small-molecules, proteins, antibodies, and nucleic acids are restricted by the BBB, which is a physical vascular barrier composed of brain endothelial cells, pericytes, and astrocytes, connected through tight junctions (Arvanitis et al., 2020 ; D'Souza et al., 2021 ). Changing characteristics or using delivery vehicles to breach the BBB has been considered more feasible than changing the permeability of BBB (Haumann et al., 2020 ).…”

Section: Challenges Of Brain Drug Deliverymentioning

confidence: 99%

“…To achieve therapeutic effects, for many drugs, they need to enter cells and reach subcellular targets. Cellular internalization of nanoparticles or drugs may involve both active transport and passive transport (Vacha et al., 2011 ; Russell et al., 2018 ; Anoop et al., 2020 ). After internalization, drug release is highly required to exerting therapeutic effect.…”

Section: Challenges Of Brain Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

From blood to brain: blood cell-based biomimetic drug delivery systems

Liu

et al. 2021

Drug Delivery

View full text Add to dashboard Cite

Brain drug delivery remains a major difficulty for several challenges including the blood-brain barrier, lesion spot targeting, and stability during circulation. Blood cells including erythrocytes, platelets, and various subpopulations of leukocytes have distinct features such as long-circulation, natural targeting, and chemotaxis. The development of biomimetic drug delivery systems based on blood cells for brain drug delivery is growing fast by using living cells, membrane coating nanotechnology, or cell membrane-derived nanovesicles. Blood cell-based vehicles are superior delivery systems for their engineering feasibility and versatile delivery ability of chemicals, proteins, and all kinds of nanoparticles. Here, we focus on advances of blood cell-based biomimetic carriers for from blood to brain drug delivery and discuss their translational challenges in the future.

show abstract

Section: Challenges Of Brain Drug Deliverymentioning

confidence: 99%

Section: Challenges Of Brain Drug Deliverymentioning

confidence: 99%

From blood to brain: blood cell-based biomimetic drug delivery systems

Liu

et al. 2021

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…The success of numerous disciplines and sciences depends on nanotechnology and nanoscience. The materials' nanoscale size makes them suitable for a variety of potential applications, including drug delivery (Anoop et al 2020), cancer treatment (Tian et al 2019), medical treatment (Devi et al 2019) and other applications. Overall, utilizing medicinal plant extracts as potential reducing and stabilizing agents for the synthesis of nanoparticles, such as ZnO nanoparticles, offers several benefits over traditional physical and extremely toxic chemical techniques (Mittal et al 2013).…”

Section: Introductionmentioning

confidence: 99%