Approaches for Assessing Health Risks from Complex Mixtures in Indoor Air: A Panel Overview

Henry, Christiani Jeyakumar; Fishbein, Lawrence; Meggs, William J.; Ash́ford, Nicholas A.; Schulte, Paul A.; Anderson, Henry A.; Osborne, Jim; Sepkovic, Daniel W.

doi:10.2307/3431120

Cited by 3 publications

(2 citation statements)

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“…The standards of comfort vary from one individual to another and in any working place, there may be some chemical-hypersensitive individuals who are adversely affected by a wide range of environmental factors at relatively low exposure levels. 14 To find out the cause, the extent and the source of this kind of discomfort in workplaces it is not enough to perform short active samplings. The measurements based on passive weekly samplings, despite the uncertainties, may give correct semi-quantitative estimates of pollutant concentrations.…”

Section: Discussionmentioning

confidence: 99%

2-Butoxyethanol from cleaning products responsible for complaints in workplaces: a case study

2012

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Indoor air quality is important because people are spending an increasing amount of time in the workplace. They are exposed to outdoor pollutants as well as pollutants emitted from products used indoors. Some chemicals, belonging to the category of volatile organic compounds (VOCs), easily release vapors at room temperature by evaporation. These accumulated vapors are often toxic and irritating. They may be alcohols, glycols, ketones, esters, etc., frequently present in the composition of many products for personal care or household purposes. This study suggests that the exposure levels of 2-butoxyethanol play an important role in the level of complaints of people at work. This study has emphasized the necessity of using different active and passive sampling methods for indoor air to avoid evaluation errors.

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Section: Discussionmentioning

confidence: 99%

2-Butoxyethanol from cleaning products responsible for complaints in workplaces: a case study

2012

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“…The major chemical constituents of indoor air are volatile organic compounds (VOCs). These substances, including formaldehyde and toluene, have been suggested to be potential causative agents of chemical sensitivity in sick building syndrome, or multiple chemical sensitivities in the home, school, and office environments (Norbäck et al, 1990;Henry et al, 1991). In addition, VOCs might contribute to the increased incidence of allergic symptoms.…”

Section: Introductionmentioning

confidence: 98%

Suppression of Th1- and Th2-type immune responses in infant mouse spleen after prenatal and postnatal exposure to low-level toluene and peptidoglycan

Yamamoto

Win-Shwe

Yoshida

et al. 2009

Inhalation Toxicology

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The aim of the present study was to investigate the effect of low-level concentrations, under the occupational acceptable limits, of toluene exposure and peptidoglycan (PGN) stimulation on Th1/Th2 immunity in infant mice. Pregnant BALB/c mice and their offspring were exposed to low-level toluene inhalation (0, 5, and 50 ppm) for 4 wk (from the late prenatal stage to early postnatal stage) in a whole-body exposure chamber. Some of the pregnant mice and their offspring were stimulated with PGN during toluene exposure. We measured total immunoglobulins of different subclasses in plasma, and production and expression level of cytokines in the lung and spleen, and transcription factors related to Th1/Th2 immunity in the spleen of infant (3 wk old) mice. Exposure of mice to 5 or 50 ppm toluene resulted in increased immunoglobulin (Ig) G1 and decreased IgG2a and IgE antibodies in the plasma; significantly decreased T-bet, GATA-3, and Foxp3 mRNA in the spleen; and a tendency toward decreased interferon (IFN)-gamma mRNA in spleen. Exposure of mice to low-level toluene together with PGN stimulation resulted in decreased IgG1 as well as IgG2a antibodies in the plasma and Foxp3 mRNA in spleen as compared with control or PGN-treated mice. These findings suggest that low-level toluene exposure and PGN stimulation from the late prenatal to early postnatal stage suppressed the splenic parameter related to Th1/Th2 immunity in infant mice.

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Evaluation Method for Improvement Efficiency of Indoor Air Quality in Residence

Yang¹,

Son²,

Yim³

2007

Korean Journal of Environmental Health Sciences

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Approaches for Assessing Health Risks from Complex Mixtures in Indoor Air: A Panel Overview

Cited by 3 publications

References 0 publications

2-Butoxyethanol from cleaning products responsible for complaints in workplaces: a case study

2-Butoxyethanol from cleaning products responsible for complaints in workplaces: a case study

Suppression of Th1- and Th2-type immune responses in infant mouse spleen after prenatal and postnatal exposure to low-level toluene and peptidoglycan

Evaluation Method for Improvement Efficiency of Indoor Air Quality in Residence

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