Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides

Shavkuta, Boris; Bardakova, Kseniia N.; Khristidis, Yana; Минаев, Н. В.; Frolova, Anastasia; Kotova, Svetlana; Aksenova, N. P.; Heydari, Zahra; Семенова, Е. Ф.; Khlebnikova, Tatyana; Голубева, Е. Н.; Kostjuk, Sergei V.; Vosough, Massoud; Timashev, Peter; Shpichka, Anastasia

doi:10.1039/d0me00157k

Cited by 5 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, such 3D scaffolds may be further considered for bone regeneration. Note also that this resin was used in [ 29 ] for the formation of microcapsules upon UV irradiation. As was shown by mechanical testing, the elastic modulus did not exceed 80 MPa, which demonstrates the importance of selecting the optimal fabrication method for the appropriate mechanical properties.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Hydrophobic Derivative of Ciprofloxacin as a New Photoinitiator of Two-Photon Polymerization: Synthesis and Usage for the Formation of Biocompatible Polylactide-Based 3D Scaffolds

et al. 2021

Self Cite

View full text Add to dashboard Cite

A hydrophobic derivative of ciprofloxacin, hexanoylated ciprofloxacin (CPF-hex), has been used as a photoinitiator (PI) for two-photon polymerization (2PP) for the first time. We present, here, the synthesis of CPF-hex and its application for 2PP of methacrylate-terminated star-shaped poly (D,L-lactide), as well a systematic study on the optical, physicochemical and mechanical properties of the photocurable resin and prepared three-dimensional scaffolds. CPF-hex exhibited good solubility in the photocurable resin, high absorption at the two-photon wavelength and a low fluorescence quantum yield = 0.079. Structuring tests showed a relatively broad processing window and revealed the efficiency of CPF-hex as a 2PP PI. The prepared three-dimensional scaffolds showed good thermal stability; thermal decomposition was observed only at 314 °C. In addition, they demonstrated an increase in Young’s modulus after the UV post-curing (from 336 ± 79 MPa to 564 ± 183 MPa, which is close to those of a cancellous (trabecular) bone). Moreover, using CPF-hex as a 2PP PI did not compromise the scaffolds’ low cytotoxicity, thus they are suitable for potential application in bone tissue regeneration.

show abstract

Section: Resultsmentioning

confidence: 99%

“…We used mesenchymal stromal cells (MSC) derived from the gingiva. The cells were cultured as described elsewhere [ 29 ] and monitored using a phase contrast microscope. A scaffold was inoculated with 50,000 cells and stained with calcein-AM (green, live cells) and propidium iodide (red, dead cells) in 5 days.…”

Section: Methodsmentioning

confidence: 99%

A Hydrophobic Derivative of Ciprofloxacin as a New Photoinitiator of Two-Photon Polymerization: Synthesis and Usage for the Formation of Biocompatible Polylactide-Based 3D Scaffolds

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similar previous studies to decipher structure-property relationships for cellular uptake of particulates emphasized single parameter, most importantly the particle size, − the particle shape, − the surface topology and charge, , and hydrophobicity, very often in complex material constructs or even by lithographic or 3D printing methods. , Here, we intentionally chose this very simple system to enable a bottom-up consideration of the final biological effects from the constitution of single particles from single polymer chains in a multivariate mode, with the goal to provide a methodological blueprint to be applied to other materials to identify specific parameters accounting for uptake in these materials.…”

Section: Introductionmentioning

confidence: 99%

Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library

Baudis,

Roch,

Balk

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Controlling cellular responses to nanoparticles so far is predominantly empirical, typically requiring multiple rounds of optimization of particulate carriers. In this study, a systematic modelassisted approach should lead to the identification of key parameters that account for particle properties and their cellular recognition. A copolymer particle library was synthesized by a combinatorial approach in soap free emulsion copolymerization of styrene and methyl methacrylate, leading to a broad compositional as well as constitutional spectrum. The proposed structure−property relationships could be elucidated by multivariate analysis of the obtained experimental data, including physicochemical characteristics such as molar composition, molecular weight, particle diameter, and particle charge as well as the cellular uptake pattern of nanoparticles. It was found that the main contributors for particle size were the polymers' molecular weight and the zeta potential, while particle uptake is mainly directed by the particles' composition. This knowledge and the reported model-assisted procedure to identify relevant parameters affecting particle engulfment of particulate carriers by nonphagocytic and phagocytic cells can be of high relevance for the rational design of pharmaceutical nanocarriers and assessment of biodistribution and nanotoxicity, respectively.

show abstract

Surface modification of polylactide films and their hydrolytic degradation performances in artificial seawater

Yao,

Li,

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Benzophenone (BP) and N‐vinylpyrrolidone (NVP) were used to modify the surface of polylactide (PLA) films by UV grafting method. The effects of light distance, temperature, reaction time, and modifier concentration on the structure and properties of PLA films were investigated by Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy (XPS), nuclear magnetic resonance spectroscopy, differential scanning calorimetry (DSC), and universal testing machine (UTM). With BP and NVP UV grafting, the hydrophilicity of PLA films is improved, but their thermal and mechanical properties are reduced under different surface modification condition. Base on the principle of good surface hydrophilicity, better mechanical and thermal properties, the hydrolytic degradation performance of modified PLA films in artificial seawater at 70°C was studied by scanning electron microscopy, XPS and DSC. The research results show that the degradation of modified PLA films mainly occurs in the amorphous region, and the degradation process conforms to surface hydrolysis mechanism. The grafting modification of NVP is better than BP to accelerate the degradation process of PLA films in artificial seawater. The degradation of modified PLA undergoes water molecule erosion and autocatalytic degradation reaction. The degradation of BP‐PLA obeys the first‐order kinetics in part, while the degradation of NVP‐PLA is more complex. Therefore, surface hydrophilicity modification is an effective technique for improving the degradability of PLA.

show abstract

Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides

Abstract: Different particles' mechanical properties and surface topography that significantly influenced the degradation rate, drug loading, and release.

Cited by 5 publications

References 55 publications

A Hydrophobic Derivative of Ciprofloxacin as a New Photoinitiator of Two-Photon Polymerization: Synthesis and Usage for the Formation of Biocompatible Polylactide-Based 3D Scaffolds

A Hydrophobic Derivative of Ciprofloxacin as a New Photoinitiator of Two-Photon Polymerization: Synthesis and Usage for the Formation of Biocompatible Polylactide-Based 3D Scaffolds

Multivariate Analysis of Cellular Uptake Characteristics for a (Co)polymer Particle Library

Surface modification of polylactide films and their hydrolytic degradation performances in artificial seawater

Contact Info

Product

Resources

About