Approach to the Patient with Platelet-Related Bleeding

Mezzano, Diego; Pereira, Jaime

doi:10.1007/978-3-319-47462-5_48

Cited by 5 publications

(2 citation statements)

References 61 publications

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“…Severe thrombocytopenia with a platelet count of less than 50 × 10 9 /L increases the risk of spontaneous skin and mucocutaneous bleeding diathesis, such as petechiae, ecchymoses, epistaxis, menorrhagia, and gastrointestinal bleeding. However, bleeding due to major hemostatic challenges (e.g., surgery and trauma) is especially frequently observed when moderate (50–100 × 10 9 platelets/L) and even mild thrombocytopenia (>100–<150 × 10 9 platelets/L) is associated with inherited or acquired platelet dysfunction [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet Phenotyping and Function Testing in Thrombocytopenia

Jurk

Shiravand

2021

JCM

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Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due to adequate point-of-care qualities. However, most of them are time-consuming, require experienced and skilled personnel for platelet handling and processing, and are therefore well-established only in specialized laboratories. This review summarizes major indications, methods/assays for platelet phenotyping, and in vitro function testing in blood samples with reduced platelet count in relation to their clinical practicability. In addition, the diagnostic significance, difficulties, and challenges of selected tests to evaluate the hemostatic capacity and specific defects of platelets with reduced number are addressed.

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Section: Introductionmentioning

confidence: 99%

Platelet Phenotyping and Function Testing in Thrombocytopenia

Jurk

Shiravand

2021

JCM

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“…Остается не изученным вопрос о возможных возраст-зависимых особенностях течения заболевания. Считается, что интенсивность кровоизлияний при первичных нарушениях гемостаза, в том числе спонтанных носовых кровотечений, может уменьшаться или даже исчезать после полового созревания [9].…”

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Age-dependent changes in platelet function of a patient with <i>SLFN14</i>-related macrothrombocytopenia

Rashevskaya,

Polokhov,

Fyodorova

et al. 2023

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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Platelet-type bleeding disorder-20 is a rare inherited thrombocytopenia caused by mutations in the SLFN14 gene. We report a case of a female patient with SLFN14 mutation, macrothrombocytopenia, severe hemorrhagic syndrome and a positive family history who was followed up from the age of 17 to 19. The 3-year follow-up showed a tendency towards partial normalization of platelet counts (from 47 to 82 × 109/L) and morphology. Platelet size and granularity as well as the density of glycoprotein (GP) membrane receptors such as GP Ib/V/IX and GP IIb/IIIa decreased. GP IIb/IIIa activation was impaired and there were no positive changes over time. The dense granules indicators were stably elevated. The parameters of a-granules (assessed by P-selectin expression) did not differ from the control group. The proportion of procoagulant phosphatidylserine-positive platelets at rest was increased and the potential to form procoagulant platelets upon activation was reduced. As the patient grew older, her bleeding disorder symptoms abated and she showed a tendency towards normalization of platelet laboratory parameters. All investigations were performed after obtaining informed consent from the patient and her parents in accordance with the Declaration of Helsinki.

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