Approach to infection and disease due to adenoviruses in solid organ transplantation

Florescu, Diana F.; Stohs, Erica

doi:10.1097/qco.0000000000000558

Cited by 15 publications

(16 citation statements)

References 77 publications

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“…The ADV infections and reinfections are more common and have more severe clinical course in immunocompromised patients, i.e. after organ transplantation [12][13]. Cancer related alterations within immune system can explain high rate of ADV presence in renal tumors, that we have noted in our study.…”

Section: Resultssupporting

confidence: 65%

Epstein-Barr virus and human adenovirus viremia in renal tumors is associated with histological features of kidney cancer

Kryst¹,

Poletajew²,

Wyczalkowska-Tomasik

et al. 2020

Preprint

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Background. There is a growing evidence that viral infections may impact the risk and clinical course of malignancies, including solid tumors. The aim of this study was to assess the possible association of selected chronic / latent viral infections with the clinical course of renal cell carcinoma (RCC).Methods. In this prospective study we enrolled 27 patients undergoing partial or radical nephrectomy due to the histologically confirmed RCC and followed them up for one year post-operation. Isolation of the nucleic acids of human adenovirus (ADV), herpes simplex virus HSV-1 and HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK virus (BKV) and John Cunningham virus (JCV) from tumor tissue was performed using the NucleoSpin Tissue Kit (Macherey-Nagel, Düren, Germany) or EZ1 Virus Mini Kit (Qiagen, Hilden, Germany). The number of viral copies in the tissue was assessed with the real-time PCR.Results. Viral infections were diagnosed in ten patients (37.0%), including three ADV cases (11.1%) and eight EBV cases (29.6%). Infected patients tended to be significantly older (71.3 vs. 57.6 years, p < 0.05), more commonly presented with chronic renal disease (OR 2.4, p < 0.05), diabetes (OR 4.2, p < 0.05) and overweight (OR 2.0, p < 0.05). Regarding oncological data, infected patients were found to have a higher rate of high-grade cancers (OR 5.0, p < 0.05) and a higher rate of papillary RCCs (OR 8.3, p < 0.05). Status of viral infections had no influence on the clinical cancer stage, surgical procedure or survival.Conclusions. EBV and ADV infections are common in renal cancer patients and increase the risk of high-grade RCC presence. While there is no significant impact on short term survival, further studies are needed to assess the relevance of these findings in a long run.Trial registration. Medical University of Warsaw KB/37/2017

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Section: Resultssupporting

confidence: 65%

Epstein-Barr virus and human adenovirus viremia in renal tumors is associated with histological features of kidney cancer

Kryst¹,

Poletajew²,

Wyczalkowska-Tomasik

et al. 2020

Preprint

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“…The ADV infections and reinfections are more common and have more severe clinical course in immunocompromised patients, i.e., after organ transplantation [ 26 , 27 ]. We hypothesized that alterations within the immune system related to carcinogenesis can increase a risk of viral infections.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Kryst

Poletajew

Wyczalkowska-Tomasik

et al. 2020

JCM

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Background: There is growing evidence that viral infections may impact the risk and clinical course of malignancies, including solid tumors. The aim of this study was to assess the possible association of selected chronic/latent viral infections with the clinical course of renal cell carcinoma (RCC). Methods: In this prospective study we enrolled 27 patients undergoing partial or radical nephrectomy due to the histologically confirmed RCC and followed them up for one year post-operation. Isolation of the nucleic acids was performed using the NucleoSpin Tissue Kit (Macherey-Nagel, Düren, Germany) from tumor tissue and using the EZ1 Virus Mini Kit v2.0 from plasma. The number of viral copies of human adenovirus (ADV), herpes simplex virus HSV-1 and HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK virus (BKV) and John Cunningham virus (JCV) in the tissue and plasma was assessed with real-time PCR. Results: Viral infections were diagnosed in ten patients (37.0%), including three ADV cases (11.1%) and eight EBV cases (29.6%). Infected patients tended to be significantly older (71.3 vs. 57.6 years, p < 0.05), more commonly presented with chronic renal disease (OR 2.4, p < 0.05), diabetes (OR 4.2, p < 0.05) and overweight (OR 2.0, p < 0.05). Regarding oncological data, infected patients were found to have a higher rate of high-grade cancers (OR 5.0, p < 0.05) and a higher rate of papillary RCCs (OR 8.3, p < 0.05). Status of viral infections had no influence on the clinical cancer stage, surgical procedure or survival. Conclusions: EBV and ADV infections are common in renal cancer patients and increase the risk of high-grade RCC presence. While there is no significant impact on short term survival, further studies are needed to assess the relevance of these findings in a long run.

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“…The recognition of the typical histopathological changes of HAdV on target organ biopsies remains the gold standard [ 50 , 51 ] for the diagnosis of acute disease. However, these methods harbor some limitations.…”

Section: Introductionmentioning

confidence: 99%

Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults

Biserni

Scarpini

Dondi

et al. 2021

Viruses

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Human Adenoviruses (HAdV) are known to be potentially associated with strong inflammatory responses and morbidity in pediatric patients. Although most of the primary infections are self-limiting, the severity of clinical presentation, the elevation of the white blood cell count and inflammatory markers often mimic a bacterial infection and lead to an inappropriate use of antibiotics. In infections caused by HAdV, rapid antigen detection kits are advisable but not employed routinely; costs and feasibility of rapid syndromic molecular diagnosis may limit its use in the in-hospital setting; lymphocyte cultures and two-sampled serology are time consuming and impractical when considering the use of antibiotics. In this review, we aim to describe the principal diagnostic tools and the immune response in HAdV infections and evaluate whether markers based on the response of the host may help early recognition of HAdV and avoid inappropriate antimicrobial prescriptions in acute airway infections.

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Approach to infection and disease due to adenoviruses in solid organ transplantation

Cited by 15 publications

References 77 publications

Epstein-Barr virus and human adenovirus viremia in renal tumors is associated with histological features of kidney cancer

Epstein-Barr virus and human adenovirus viremia in renal tumors is associated with histological features of kidney cancer

Epstein-Barr Virus and Human Adenovirus Viremia in Renal Tumors Is Associated with Histological Features of Malignancy

Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults

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