Appraising SARS-CoV-2 infections after full mRNA COVID-19 vaccination in patients with systemic lupus erythematosus (SLE)

Considerations on COVID-19 vaccination

“…Anuforo and coworkers described three cases of patients with systemic lupus erythematosus (SLE) and comorbidities who contracted COVID-19 after vaccination with mRNA vaccines, resulting in two inpatient hospital admissions (one patient was managed in ambulatory settings [8] . Somehow confirming the concept that an autoimmune background could influence responses to COVID-19 mRNA vaccines, one patient with a history of Raynaud's disease, leukocytoclastic vasculitis, hand arthritis, and Sjogren's syndrome developed cryoglobulinemia, hypocomplementemia, elevated antinuclear antibodies (ANA), IgM antiphospholipid autoantibodies and digital necrosis after vaccination [9] .…”