Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations

Labib, Rola M.; Ayoub, Iriny M.; Michel, Haidy E.; Mehanny, Mina; Kamil, Verena; Hany, Meryl; Magdy, Mirette; Moataz, Aya; Maged, Boula; Mohamed, A.H.

doi:10.1371/journal.pone.0219561

Cited by 55 publications

(46 citation statements)

References 38 publications

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“…Essential oil components were elucidated from their mass spectra and retention indices (RIs) relative to a mixture of a homologous series of standard n ‐alkanes (C 8 –C 28 ) injected under the same conditions. These data were compared with NIST‐11, Wiley Registry of Mass Spectral Database and data reported in the literature 6,11–17 …”

Section: Methodsmentioning

confidence: 99%

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Phytochemical discrimination of Pinus species based on GC–MS and ATR‐IR analyses and their impact on Helicobacter pylori

Gad

Al‐Sayed

Ayoub

2021

Phytochemical Analysis

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Introduction The leaves and cones of Pinus plants as well as their essential oils have been used in traditional medicine for the treatment of several ailments. Objectives Phytochemical discrimination of Pinus species and investigation of their anti‐Helicobacter pylori activity in vitro and in silico. Materials and Methods Gas chromatography–mass spectrometry (GC–MS) and attenuated total reflectance infrared (ATR‐IR) metabolic profiling of the essential oils of Pinus species. Principal component analysis (PCA) and hierarchal cluster analysis (HCA) were applied for discrimination and segregation of Pinus species. Results GC–MS revealed the presence of 76 constituents, where monoterpenes represented the major class with the dominance of α‐pinene (72%) followed by β‐pinene (16%) for P. canariensis. β‐Pinene was the dominant component in P. pinea (24%) followed by terpinolene (11%). α‐Pinene (17%) and caryophyllene (12%) were the major components in P. halepensis, while, 3‐carene (33%) and α‐pinene (17%) represented the major constituents of P. roxburghii oil. By applying PCA and HCA on GC–MS and ATR‐IR data analysis, ATR‐IR displayed much better discrimination for Pinus species. The pine oils showed promising inhibitory effects on Helicobacter pylori. Furthermore, in silico molecular modelling was carried out where the calculated free binding energies of phytochemicals identified ranged from −33.71 to −19.67 kcal/mol for urease and −41.18 to −16.57 kcal/mol for shikimate kinase. This suggests favourable binding of pine essential oil components to both enzymes, thus explaining their potential inhibitory activity on H. pylori. Conclusion GC–MS and ATR‐IR based metabolic analyses could discriminate between Pinus species. Pine essential oils can be used as promising therapeutic drugs to protect against H. pylori infection.

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Section: Methodsmentioning

confidence: 99%

“…These data were compared with NIST-11, Wiley Registry of Mass Spectral Database and data reported in the literature. 6,[11][12][13][14][15][16][17]…”

Section: Analysis Of Essential Oils By Gc-msmentioning

confidence: 99%

Phytochemical discrimination of Pinus species based on GC–MS and ATR‐IR analyses and their impact on Helicobacter pylori

Gad

Al‐Sayed

Ayoub

2021

Phytochemical Analysis

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“…An increase in the number of blood vessels and fibroblasts, through cyclin-D1 pathway activation and enhanced expression of Bcl-2, was also observed [ 190 ]. A positive effect on wound healing process has also been described for other EOs such as lavender EO, TTO, Alpinia zerumbet and Chrysantemum boreale Makino EO and their use has been suggested for the treatment of wounds, burns, abscesses or diseases such as diabetes [ 191 , 192 , 193 , 194 ]. Thus, the antiangiogenic property or the positive effect on wound healing showed by some EOs should be considered when proposing them for treatment of cancer or other diseases.…”

Section: Mechanism Of Action Of Eos In Melanomamentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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“…Essential oils contain many chemical compounds (monoterpene hydrocarbons, oxygenated monoterpenes, sesquiterpene hydrocarbons, oxygenated sesquiterpenes, and others) which are not stable [ 1 , 2 , 3 ]. Essential oils not only have an odor or flavor [ 4 ] but they also have antibacterial [ 5 , 6 ], antioxidant [ 2 , 7 ], and many pharmaceutical effects: they decrease pain [ 8 , 9 ], reduce inflammation [ 10 ], and promote wound healing [ 11 , 12 ]. For instance, for nutmeg, its essential oil has antibacterial, antioxidant, anti-inflammatory, and insecticidal effects [ 1 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Development of New Formula Microcapsules from Nutmeg Essential Oil Using Sucrose Esters and Magnesium Aluminometasilicate

2020

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Essential oils are volatile liquids which evaporate and lose their pharmacological effect when exposed to the environment. The aim of this study is to protect nutmeg essential oil from environmental factors by encapsulation (shell material, sodium alginate) and determine the influence of crosslinker concentration (2%, 5% calcium chloride), different emulsifiers (polysorbate 80, sucrose esters), and magnesium aluminometasilicate on microcapsule physical parameters, encapsulation efficiency (EE), swelling index (SI), and other parameters. Nutmeg essential oil (NEO)-loaded calcium alginate microcapsules were prepared by extrusion. The swelling test was performed with and without enzymes in simulated gastric, intestinal, and gastrointestinal media. This study shows that the crosslinker concentration has a significant influence on EE, with 2% calcium chloride solution being more effective than 5%, and capsules being softer with 2% crosslinker solution. Using sucrose esters, EE is higher when polysorbate 80 is used. The swelling index is nearly three times higher in an intestinal medium without enzymes than in the medium with pancreatin. Microcapsule physical parameters depend on the excipients: the hardest capsules were obtained with the biggest amount of sodium alginate; the largest with magnesium aluminometasilicate. Sucrose esters and magnesium aluminometasilicate are new materials used in extrusion.

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Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations

Cited by 55 publications

References 38 publications

Phytochemical discrimination of Pinus species based on GC–MS and ATR‐IR analyses and their impact on Helicobacter pylori

Phytochemical discrimination of Pinus species based on GC–MS and ATR‐IR analyses and their impact on Helicobacter pylori

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Development of New Formula Microcapsules from Nutmeg Essential Oil Using Sucrose Esters and Magnesium Aluminometasilicate

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