Appraisal of the pediatric ulcerative colitis activity index (PUCAI)

Turner, Dan; Hyams, Jeffrey S.; Markowitz, James; Lerer, Trudy; Mack, David R.; Evans, Jonathan; Pfefferkorn, Marian D.; Rosh, Joel R.; Kay, Marsha; Crandall, Wallace; Keljo, David J.; Otley, Anthony; Kugathasan, Subra; Carvalho, Ryan; Oliva-Hemker, Maria; Langton, Christine R.; Mamula, Petar; Bousvaros, Athos; LeLeiko, Neal S.; Griffiths, Anne M.

doi:10.1002/ibd.20867

Cited by 267 publications

(216 citation statements)

References 33 publications

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“…BMI was converted to BMI z-scores according to growth curves of the general Greek pediatric population. Disease activity was quantified using the Pediatric Crohn's Disease Activity Index (37) and Pediatric Ulcerative Colitis Activity Index (38). Both these indexes have been validated in pediatric populations with IBD, with higher values corresponding to higher disease activity.…”

Section: Methodsmentioning

confidence: 99%

Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn’s disease and ulcerative colitis

et al. 2013

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Background: Crohn's disease (CD) and ulcerative colitis (UC) result in metabolic consequences. We assessed circulating leptin and adiponectin concentrations and examined their relations to glucose metabolism in children with CD and UC. Methods: Circulating morning fasting concentrations of leptin, adiponectin, glucose, and insulin were measured in 32 children with CD and 18 children with UC. Insulin resistance (IR) and β-cell function were evaluated by the updated homeostatic model assessments (HOMA2-IR and HOMA2-B). results: Leptin was positively related to BMI z-scores overall and in the CD and the UC subgroups (P < 0.001). A negative correlation between leptin and disease activity was observed in the entire population (P = 0.034) and in the UC (P = 0.03) group. None of the assessed parameters was related to adiponectin. Fourteen percent of the participants were insulin resistant (15.6% in the CD group and 11.1% in the UC group), significantly more than expected (P < 0.001). Leptin was associated with HOMA2-IR (overall: r = 0.29, P = 0.045). Pathway analysis suggested that, overall, disease activity and BMI significantly affect leptin, which in turn is the only correlate of HOMA2-IR. conclusion: Disease activity was significantly and inversely related to leptin in children with inflammatory bowel disease (IBD). A significant proportion of the patients had increased IR, which is positively related to circulating leptin. c rohn's disease (CD) and ulcerative colitis (UC) are inflammatory conditions of the intestines, often collectively referred to as inflammatory bowel diseases (IBDs). They are characterized by a chronic course with significant morbidity and require long-term medications and care. It is now recognized that IBDs are not just diseases of the bowels, but rather systemic disorders with frequent extraintestinal manifestations (1). In children, such complications include, among others, altered body composition, malnutrition, and metabolic disturbances, with the last being probably the least studied. Endocrine dysfunction in pediatric IBD, although recognized for more than 30 y (2), has not been extensively investigated. Growth impairment, being the most frequent endocrine disorder encountered

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Section: Methodsmentioning

confidence: 99%

Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn’s disease and ulcerative colitis

et al. 2013

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“…Even in a prospectively collected ''real-life'' registry cohort, the PCDAI was scored in only 48% of eligible visits compared with 98% for the Pediatric Ulcerative Colitis Activity Index (PUCAI), which requires no laboratory values. 6 A recent study has found that data to complete the PCDAI retrospectively were available in the charts of only 20% of 3643 clinical visits. 7 Second, although the height item undoubtedly is a very important marker of disease activity in children, it is relevant only to young children in the Tanner-growing stages (until stages 2-3) and its calculation over many months reduces short-term responsiveness and discriminant validity.…”

mentioning

confidence: 99%

Mathematical weighting of the pediatric Crohnʼs disease activity index (PCDAI) and comparison with its other short versions

Turner¹,

Griffiths²,

Walters³

et al. 2012

Inflammatory Bowel Diseases

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“…These six variables are abdominal pain, rectal bleeding, stool consistency, nocturnal stools, number of stools each 24 hours and interruption to normal activities. The PUCAI correlates closely with other indicators, such as physician global assessment and endoscopic scores (Turner et al 2009). This validated score, which is simple and non-invasive, can now be used to assess disease activity and to monitor changes in activity following intervention.…”

Section: Inflammatory Markers and Disease Activity In Paediatric Ucmentioning

confidence: 87%

Ulcerative Colitis in Children and Adolescents

Day¹,

Lemberg²

2011

Ulcerative Colitis - Treatments, Special Populations and the Future

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Appraisal of the pediatric ulcerative colitis activity index (PUCAI)

Abstract: This study on real-life, prospectively obtained data confirms that the PUCAI is highly feasible by virtue of the noninvasiveness, valid, and responsive index. The PUCAI can be used as a primary outcome measure to reflect disease activity in pediatric UC.

Cited by 267 publications

References 33 publications

Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn’s disease and ulcerative colitis

Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn’s disease and ulcerative colitis

Mathematical weighting of the pediatric Crohnʼs disease activity index (PCDAI) and comparison with its other short versions

Ulcerative Colitis in Children and Adolescents

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