Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed

Rahman, Afaf N. Abdel; Mohamed, Amany Abdel-Rahman; Dahran, Naief; Farag, Mohamed F.M.; Alqahtani, Leena S.; Nassan, Mohamed A.; Althobaiti, Saed A.; El-naseery, Nesma I.

doi:10.1016/j.aquatox.2022.106257

Cited by 17 publications

(9 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current study confirmed this via the downregulated expression of mitochondrial Complex genes ( I-V ) in the brain tissue of the FNE group rather than the control. Other pyrethroids, including cypermethrin and deltamethrin, have also been documented to cause oxidative stress in cells ( Mohamed et al, 2020 ; Rahman et al, 2022 ), thus confirming our findings.…”

Section: Discussionsupporting

confidence: 91%

Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles

Alotaibi,

Abdel-Rahman Mohamed,

Abd-Elhakim

et al. 2024

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Introduction: The synthetic pyrethroid derivative fenpropathrin (FNE), a commonly used insecticide, has been associated with various toxic effects in mammals, particularly neurotoxicity. The study addressed the hallmarks of the pathophysiology of Parkinson’s disease upon oral exposure to fenpropathrin (FNE), mainly the alteration of dopaminergic markers, oxidative stress, and molecular docking in rat models. In addition, the protective effect of curcumin-encapsulated chitosan nanoparticles (CRM-Chs-NPs) was also assessed. Methods: In a 60-day trial, 40 male Sprague Dawley rats were divided into 4 groups: Control, CRM-Chs-NPs (curcumin-encapsulated chitosan nanoparticles), FNE (15 mg/kg bw), and FNE + CRM-Chs-NPs. Results: FNE exposure induced reactive oxygen species generation, ATP production disruption, activation of inflammatory and apoptotic pathways, mitochondrial function and dynamics impairment, neurotransmitter level perturbation, and mitophagy promotion in rat brains. Molecular docking analysis revealed that FNE interacts with key binding sites of dopamine synthesis and transport proteins. On the other hand, CRM-Chs-NPs mitigated FNE’s toxic effects by enhancing mitochondrial dynamics, antioxidant activity, and ATP production and promoting anti-inflammatory and antiapoptotic responses.Conclusion: In summary, FNE appears to induce dopaminergic degeneration through various mechanisms, and CRM-Chs-NPs emerged as a potential therapeutic intervention for protecting the nervous tissue microenvironment.

show abstract

Section: Discussionsupporting

confidence: 91%

Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles

Alotaibi,

Abdel-Rahman Mohamed,

Abd-Elhakim

et al. 2024

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Apoptosis and autophagy are recognized as significant contributors to tissue injury in the mechanism of pesticide toxicity, as they represent two distinct modes of regulated cell death [ 12 , 52 , 53 ]. Numerous studies have found that DEL exposure can induce mitochondrial-mediated apoptosis by increasing the expression of inflammatory (caspase 1), apoptosis initiators (caspase 8), or executioners (caspases 3 and 7) [ 10 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Conventional Anthelmintic Concentration of Deltamethrin Immersion Disorder in the Gill Immune Responses of Crucian Carp

Wu,

Yuan,

Gao

et al. 2023

Toxics

View full text Add to dashboard Cite

Current treatment strategies for parasitic infectious diseases in crucian carp primarily rely on chemotherapy. As a commonly used antiparasitic agent, deltamethrin (DEL) may have the potential adverse effects on external mucosa of fish such as gills. In this study, 180 healthy juvenile crucian carp (Carassius auratus) (average weight: 8.8 ± 1.0 g) were randomly divided into three groups for 28 days, which were immersed in 0 μg/L, 0.3 μg/L, and 0.6 μg/L of DEL, respectively. The results of histological analysis revealed that severe hyperplasia in the secondary lamellae of gills was observed, and the number of goblet (mucus-secreting) cells increased significantly after DEL immersion. TUNEL staining indicated that the number of apoptotic cells increased in crucian carp gill. At the molecular level, the mRNA expression analysis revealed significant upregulation of apoptosis (caspase 3, caspase 8, and bax), autophagy (atg5 and beclin-1), and immune response (lzm, muc5, il-6, il-8, il-10, tnfα, ifnγ, tgfβ, tlr4, myd88, and nf-kb), whereas tight junction-related genes (occludin and claudin12) were downregulated after DEL immersion, suggesting that DEL immersion altered innate immunity responses and promoted mucus secretion. Moreover, tandem mass tag (TMT)-based proteomics revealed that a total of 428 differentially expressed proteins (DEPs) contained 341 upregulated DEPs and 87 downregulated DEPs with function annotation were identified between the control and DEL groups. Functional analyses revealed that the DEPs were enriched in apoptotic process, phagosome, and lysosome pathways. Additionally, DEL immersion also drove gill microbiota to dysbiosis and an increase in potentially harmful bacteria such as Flavobacterium. Overall, this study showed that DEL elicited shifts in the immune response and changes in the surface microbiota of fish. These results provide new perspectives on the conventional anthelmintic concentration of DEL immersion disorder of the gill immune microenvironment in crucian carp and theoretical support for future optimization of their practical application.

show abstract

“…When external environmental factors impact fish, they are usually reflected in blood indicators (Casanovas et al, 2021;Witeska et al, 2022). Some serum enzymes and metabolites are widely used as a reflection of liver functional statuses in fish, such as alkaline phosphatase (AKP, Casillas and Ames, 1985), acid phosphatase (ACP, Molayemraftar et al, 2022), alanine aminotransferase (ALT, Kim and Kang, 2016;Zhang et al, 2016), aspartate aminotransferase (AST, Kim and Kang, 2016;Zhang et al, 2016), lactate dehydrogenase (LDH, Rahman et al, 2022) and albumin (ALB, Mukherjee et al, 2022). In the present study, ALT was only significantly higher in the D-LD group than in the L-LD group.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the liver is the central organ of metabolism, and metabolic disorders caused by the absence of photoperiod are often accompanied by liver damage. Under the healthy condition, there is abundant acid phosphatase (ACP), alkaline phosphatase (AKP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) in the liver, and once the liver is injured, these enzymes will be released into the blood, so the activity of these enzymes in the serum are widely used as indicators of liver damage (Molayemraftar et al, 2022;Rahman et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Effects of different photoperiods and feeding regimes on immune response, oxidative status, and tissue damage in juvenile rainbow trout (Oncorhynchus mykiss)

Shi

et al. 2022

Front. Mar. Sci.

View full text Add to dashboard Cite

A three-month culture experiment was conducted to investigate the effects of the feeding regime on liver health, non-specific immunity, and apoptosis of juvenile rainbow trout under constant light conditions. A total of six experimental groups contained two photoperiods [LL (24L:0D) and LD (12L:12D)] and three feeding regimes [R (random feeding), D (mid-dark stage feeding), L (mid-light stage feeding)], defined as R-LL, D-LL, L-LL, R-LD, D-LD, L-LD. The experiment results revealed a significantly higher alanine aminotransferase (ALT) level in the nocturnal feeding group (D-LD) and significantly higher aspartate aminotransferase (AST) in the R-LL and D-LL groups, indicating possible liver damage in these groups. In addition, high serum levels of immunoglobulins M (IgM), complement 3 (C3), and complement 4 (C4) were observed in the LL (compared to LD), R (LL conditions), and D (LD conditions) groups, suggesting that stress may be present in these groups. Meanwhile, under LL, high cytokine genes (tnf-α, il-1β, il-6, and il-8) expression were observed in the liver and intestine of the L group, possibly reflecting a stronger immune response. In the liver, high malondialdehyde (MDA) content was observed in the LL (compared to LD), R (LD conditions), and D (LL conditions) groups, suggesting that these groups were subjected to oxidative damage. Further, higher apoptosis genes (cytc and bcl-2) expression in the liver was detected in the R and D-LD groups. The highest level of hepatic apoptotic cells was also observed in the D-LD group. Taken together, long-term exposure to LL, random feeding, and nocturnal feeding can cause oxidative damage to juvenile rainbow trout, leading to hepatocyte apoptosis, while scheduled diurnal feeding can alleviate the oxidative damage caused by LL.

show abstract

Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed

Cited by 17 publications

References 87 publications

Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles

Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles

Conventional Anthelmintic Concentration of Deltamethrin Immersion Disorder in the Gill Immune Responses of Crucian Carp

Effects of different photoperiods and feeding regimes on immune response, oxidative status, and tissue damage in juvenile rainbow trout (Oncorhynchus mykiss)

Contact Info

Product

Resources

About