Appraisal of DNA obligatory, DNA cleavage and in vitro anti-biogram efficiency of 9,10-phenanthrenequinone based metal complexes

Raman, Natarajan; Arun, T.; Mahalakshmi, Rajkumar; Packianathan, Seemon; Antony, R.

doi:10.1016/j.inoche.2014.06.011

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Cobalt(III) and ruthenium (II) complexes that can intercalate between the stacked base pairs of native DNA have been actively investigated as probes [90][91][92][93][94] of DNA structure in solution and as stereoselective or conformation-specific agents for the photoactivated cleavage of DNA [95,96]. The nature of the interactions between cobalt (III) and ruthenium(II) complexes and others [97,98] and DNA have primarily been studied by cyclic voltammetry [96,[99][100][101][102][103][104], spectroscopic [105][106][107][108][109], and X-ray crystallographic methods [105], to name a few.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Beebe¹,

Celestine

Bullock

et al. 2020

Journal of Inorganic Biochemistry

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× 10 5 and 1.6 × 10 4 M −1 , respectively). Topoisomerase inhibition assays and cleavage studies proved that complex 4 was an efficient catalytic inhibitor of human topoisomerases I and IIα. Based upon the results obtained from the 3-(4,5-dimethylthiazol-2-yl)-5-(3carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay on 4T1-luc metastatic mammary breast cancer cells (IC 50 = 34.4 ± 5.2 μM when compared to IC 50 = 13.75 ± 1.08 μM for the control, cisplatin), further investigations into the molecular events initiated by exposure to complex 4 were investigated. Studies have shown that complex 4 activated both the apoptotic and autophagic signaling pathways in addition to causing dissipation of the mitochondrial membrane potential (ΔΨ m). Furthermore, activation of cysteine-aspartic proteases3 (caspase 3) in a time-and concentration-dependent manner coupled with the ΔΨ m , studies implicated the intrinsic apoptotic pathway as the major regulator of cell death mechanism.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Beebe¹,

Celestine

Bullock

et al. 2020

Journal of Inorganic Biochemistry

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“…The bio‐interested transition metal complexes can interact with such DNA binding sites either by covalent or non‐covalent binds (intercalation, groove binding, electrostatic forces and hydrogen bonding). These kinds of interactions presented by metal complexes toward DNA are currently fascinated owing to the role of metal complexes as DNA structural probes, DNA foot printers, sequence‐specific cleavage agents and potential anticancer drugs . Metal complexes such as nickel, copper, cobalt and zinc with N‐containing ligands have exerted amazing binding and cleavage activities.…”

Section: Introductionmentioning

confidence: 99%

New transition metal complexes of 9,10‐phenanthrenequinone p‐toluyl hydrazone Schiff base: Synthesis, spectroscopy, DNA and HSA interactions, antimicrobial, DFT and docking studies

Moradinia

Mansournia

Aramesh‐Boroujeni

et al. 2019

Applied Organom Chemis

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The new complexes of Cu (II) and Ni (II) of a tridentate Schiff base ligand derived from 9,10‐phenanthrenequinone and p‐toluic hydrazide have been synthesized and characterized by elemental analysis, electrical conductometry, FT‐IR, Mass, NMR and UV–Vis. The DFT calculations were carried out at B3LYP/6‐31G*(d) level for the determination of the optimized structure of the ligand and its complexes. The as‐synthesized compounds were screened for their antimicrobial activity. Also, their binding behavior with fish salmon‐DNA (FS‐DNA) and human serum albumin (HSA) were studied by different kinds of spectroscopic and molecular modeling techniques. The fluorescence data at different temperatures were applied in order to estimate the thermodynamics parameters of interactions of ligand and its complexes with DNA and HSA. The results showed that the as‐made compounds could bind to FS‐DNA and HSA via the groove binding as the major binding mode. According to molecular docking calculation and competitive binding experiments, these compounds bind to the minor groove of DNA and hydrophobic residues located in the subdomain IB of HSA. In addition, the molecular docking results kept in good consistence with experimental data.

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Biological screening and DNA nuclease activity of transition metal complexes of N₂O₂type of Knoevenagel condensate Schiff base

Pandiyan¹,

Raman²

2016

Applied Organom Chemis

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A novel tetradentate N2O2 type of Knoevenagel condensate Schiff base, synthesized from 4‐amino‐2,3‐dimethyl‐1‐phenyl‐3‐pyrazolin‐5‐one (4‐aminoantipyrine) and 3‐(cinnamyl)‐pentane‐2,4‐dione, forms stable complexes with transition metal ions such as Cu(II), Co(II), Ni(II) and Zn(II). The structural features were derived from elemental analysis, molar conductance measurements, infrared, UV–visible, 1H NMR, 13C NMR, mass and electron paramagnetic resonance spectroscopies. These complexes show high conductance values, supporting their electrolytic nature. Spectroscopic and other analytical data of the complexes suggest square planar geometry. In vitro calf thymus DNA binding studies were performed by employing UV–visible absorption spectroscopy, viscometry and cyclic voltammetry. These techniques indicate that all the metal complexes bind to DNA via intercalation mode. Antimicrobial screening of the synthesized ligand and complexes was conducted against Gram‐positive bacteria, Gram‐negative bacteria and fungi. These complexes exhibit higher antimicrobial activities than the free Schiff base, as investigated using the minimum inhibitory concentration method. Gel electrophoresis reveals that these complexes also promote the cleavage of pUC18 plasmid DNA in the presence of activators. Copyright © 2016 John Wiley & Sons, Ltd.

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Appraisal of DNA obligatory, DNA cleavage and in vitro anti-biogram efficiency of 9,10-phenanthrenequinone based metal complexes

Cited by 6 publications

References 26 publications

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

New transition metal complexes of 9,10‐phenanthrenequinone p‐toluyl hydrazone Schiff base: Synthesis, spectroscopy, DNA and HSA interactions, antimicrobial, DFT and docking studies

Biological screening and DNA nuclease activity of transition metal complexes of N₂O₂type of Knoevenagel condensate Schiff base

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Appraisal of DNA obligatory, DNA cleavage and in vitro anti-biogram efficiency of 9,10-phenanthrenequinone based metal complexes

Cited by 6 publications

References 26 publications

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

New transition metal complexes of 9,10‐phenanthrenequinone p‐toluyl hydrazone Schiff base: Synthesis, spectroscopy, DNA and HSA interactions, antimicrobial, DFT and docking studies

Biological screening and DNA nuclease activity of transition metal complexes of N2O2type of Knoevenagel condensate Schiff base

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Biological screening and DNA nuclease activity of transition metal complexes of N₂O₂type of Knoevenagel condensate Schiff base