Applying the new guidelines to asthma management in children

Abstract

Purpose of reviewThis review aims to provide paediatricians with novel concepts from scientific evidence applicable to treating children with asthma. The latest guideline updates on paediatric asthma are discussed here, with a focus on the 2022 update of the GINA document. Recent findingsMild asthma remains to be an important challenge for the paediatrician, and the introduction of new evidence-based treatment strategies, particularly those symptom-driven, could have a significant impact on the paediatric population. The identification of predictive biomarkers, the definition of biological treatment response, the possible duration of these therapies in this age group, as well as their potential action on airway remodelling are desirable in the short term. As the number of available biological treatment options expands, paediatricians should be supported by further evidence in decision-making. SummaryThere is an urgent need to implement at multiple levels the latest therapeutic strategies proposed for asthma at all severities.

Maternal gestational diabetes mellitus and the childhood asthma in offspring: a meta-analysis

“…If there were discrepancies, discussion with the corresponding author was indicated to resolve them. The extracted data included the following: [ 1 ] study information (authors, countries, publication year, and study design); [ 2 ] numbers of mother-child pairs included, maternal age at index birth, methods for validation of GDM, and numbers of women with GDM; [ 3 ] age of children at the diagnosis of asthma, sex of offspring, methods for validation of asthma in children, numbers of children who developed asthma; and [ 4 ] variables included in the multivariate regression analysis for the association between maternal GDM and asthma in offspring.…”

“…Asthma is a chronic and allergic disease which usually starts in childhood. Children with asthma experience respiratory symptoms such as wheezing, coughing, shortness of breath, chest tightness, as well as variable airflow limitation [ 1 , 2 ]. Accumulating evidence suggests that prevalence of childhood asthma, as well as that of allergic diseases, has risen dramatically from the middle of the 20th century in developed countries, probably due to the changes of environmental exposures and lifestyles [ 3 , 4 ].…”

New approaches in childhood asthma treatment

“…In the pediatric age group, 'intermittent' and 'mildpersistent' account for the vast majority of asthma phenotypes [5][6][7][8][9][10]. As described in the British National Review of Asthma Deaths report in 2014, mild asthma is associated with a considerable risk of severe and, potentially, fatal acute attacks [11].…”

Pediatric asthma and development of atopy 2023

“…Pediatricians need suitable innovative ideas from scientific evidence to manage pediatric patients with asthma. Castagnoli et al [5] review the newest guideline updates on pediatric asthma, emphasizing the 2022 update of the Global Initiative for Asthma document. There is a pressing demand to enforce at several levels the newest treatment options suggested for asthma at all gravity.…”