Applying the emergency risk management process to tackle the crisis of antibiotic resistance

Dominey‐Howes, Dale; Bajorek, Beata; Michael, Carolyn Anne; Betteridge, Brittany; Iredell, Jonathan R.; Labbate, Maurizio

doi:10.3389/fmicb.2015.00927

Cited by 13 publications

(10 citation statements)

References 28 publications

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“…This is in line with the importance of grain filling traits under stress reported in drought conditions (Assefa et al 2013). In LP conditions yield, seed and pod number per area and biomass traits were significantly negatively correlated with DF and DPM, indicating that stress avoidance by early maturity combined with greater physiological efficiency (i.e., more yield per day; Polania et al 2016a) is an important tolerance mechanism. This is again similar to observations in drought stress conditions underlining the similar mechanism for tolerance to these different stress conditions (Beebe et al 2013).…”

Section: Low P Stress Shows Similarities To Drought Stresssupporting

confidence: 85%

“…Transgressive segregation beyond the parental lines was observed for most traits, indicating promising combinations of parental alleles. Most pronounced positive transgressive segregation was observed for CID where most RILs displayed higher values of CID than the parental lines suggesting higher stomatal conductance and metabolic activity in these lines for effective use of water (Polania et al 2016a).…”

Section: Phenotypic Evaluation Of the Dxg Ril Population In Contrastimentioning

confidence: 96%

“…Investigated photosynthetic traits were SPAD chlorophyll meter reading in younger fully expanded leaf (SCMR) in SPAD units, stomatal conductance on younger fully expanded leaf (SCOND) in mmol m -2 s -1 , photosynthetic efficiency on younger fully expanded leaf (FVFM) as fv`/ fm`, and carbon isotope discrimination (CID) in ‰ (Beebe et al 2013;Dhanapal et al 2015;Polania et al 2016a). Additional information about the traits can be found in the "Trait Dictionaries for Fieldbook Development" at http://mbp.generationcp.org and http://www.cropontology-curationtool.org/.…”

Section: Experimental Design and Field Conditionsmentioning

confidence: 99%

“…13 C and 12 C are present in the biosphere naturally at 1.1 % and 98.9 %, respectively. Plants may discriminate against the heavier isotope δ 13 C at the Calvin cycle depending on stomatal activity, which leads to a depletion of the plant dry matter in 13 C. Different studies have demonstrated that CID is correlated with water use efficiency (WUE) allowing to identify indirectly genotypes that tolerate water limited conditions (Dhanapal et al 2015;Polania et al 2016a). This trait showed stability across environments and high broad sense heritability (Dhanapal et al 2015) .…”

mentioning

confidence: 99%

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Phenotypic evaluation and QTL analysis of yield and symbiotic nitrogen fixation in a common bean population grown with two levels of phosphorus supply

et al. 2017

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Phenotypic evaluation and QTL analysis of yield and symbiotic nitrogen fixation in a common bean population grown with two levels of phosphorus supply The International Center for Tropical Agriculture (CIAT) believes that open access contributes to its mission of reducing hunger and poverty, and improving human nutrition in the tropics through research aimed at increasing the eco-efficiency of agriculture. CIAT is committed to creating and sharing knowledge and information openly and globally. We do this through collaborative research as well as through the open sharing of our data, tools, and publications.

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Section: Low P Stress Shows Similarities To Drought Stresssupporting

confidence: 85%

Section: Phenotypic Evaluation Of the Dxg Ril Population In Contrastimentioning

confidence: 96%

Section: Experimental Design and Field Conditionsmentioning

confidence: 99%

mentioning

confidence: 99%

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Phenotypic evaluation and QTL analysis of yield and symbiotic nitrogen fixation in a common bean population grown with two levels of phosphorus supply

et al. 2017

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“… 19 The WHO also gave a report to examine antibiotic resistance globally in 2014 and held a high level global assembly to call for all countries and regions of the world to take actions to address this urgent problem. 20 QAs were found to be invulnerable to developing antimicrobial resistance in S. mutans and Enterococcus faecalis in vitro . 21 Recently, we found that quaternary ammonium monomers could induce drug resistance in Streptococcus gordonii .…”

Section: Introductionmentioning

confidence: 99%

Quaternary ammonium-induced multidrug tolerant Streptococcus mutans persisters elevate cariogenic virulence in vitro

et al. 2017

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Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds (QAs) have been developed to preveFnt or treat dental caries. However, there is no report on the tolerance of S. mutans to QAs. In this study, we investigated the development of S. mutans persistence induced by a novel dental caries defensive agent, dimethylaminododecyl methacrylate (DMADDM), for the first time. Typical biphasic killing kinetics for persisters were observed in both S. mutans planktonic and biofilm cultures challenged by DMADDM at concentrations of 20 and 200 μg·mL−1, respectively. The persisters tolerated six other antibiotics with different antibacterial mechanisms, while only daptomycin and vancomycin could slightly reduce the persister numbers in planktonic cultures. The distribution of persisters in DMADDM-treated biofilms was similar to that in the untreated control, except that the total biomass and biofilm height were significantly reduced. A higher exopolysaccharides (EPS):bacteria ratio was observed in DMADDM-treated biofilms. Persisters in biofilms significantly upregulated gtf gene expression, indicating an increase in the bacteria’s ability to produce EPS and an elevated capability of cariogenic virulence. Carbon source metabolism was significantly reduced, as related metabolic genes were all downregulated in persisters. Concentrations of 0.1 mM, 1 mM and 10 mM of extra glucose significantly reduced the number of persisters both in planktonic and biofilm conditions. The formation of non-inheritable and multidrug tolerant persisters induced by DMADDM suggested that drug tolerance and new persistent eradication strategies should be considered for oral antibacterial agents.

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Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity

et al. 2019

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Antimicrobial peptides (AMPs) kill bacteria by targeting their membranes through various mechanisms involving peptide assembly, often coupled with disorder‐to‐order structural transition. However, for several AMPs, similar conformational changes in cases in which small organic compounds of both endogenous and exogenous origin have induced folded peptide conformations have recently been reported. Thus, the function of AMPs and of natural host defence peptides can be significantly affected by the local complex molecular environment in vivo; nonetheless, this area is hardly explored. To address the relevance of such interactions with regard to structure and function, we have tested the effects of the therapeutic drug suramin on the membrane activity and antibacterial efficiency of CM15, a potent hybrid AMP. The results provided insight into a dynamic system in which peptide interaction with lipid bilayers is interfered with by the competitive binding of CM15 to suramin, resulting in an equilibrium dependent on peptide‐to‐drug ratio and vesicle surface charge. In vitro bacterial tests showed that when CM15⋅suramin complex formation dominates over membrane binding, antimicrobial activity is abolished. On the basis of this case study, it is proposed that small‐molecule secondary structure regulators can modify AMP function and that this should be considered and could potentially be exploited in future development of AMP‐based antimicrobial agents.

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Applying the emergency risk management process to tackle the crisis of antibiotic resistance

Cited by 13 publications

References 28 publications

Phenotypic evaluation and QTL analysis of yield and symbiotic nitrogen fixation in a common bean population grown with two levels of phosphorus supply

Phenotypic evaluation and QTL analysis of yield and symbiotic nitrogen fixation in a common bean population grown with two levels of phosphorus supply

Quaternary ammonium-induced multidrug tolerant Streptococcus mutans persisters elevate cariogenic virulence in vitro

Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity

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