Applying Flow Virometry to Study the HIV Envelope Glycoprotein and Differences Across HIV Model Systems
Jonathan Burnie,
Claire Fernandes,
Ayushi Patel
et al.
Abstract:The HIV envelope glycoprotein (Env) is a trimeric protein that facilitates viral binding and fusion with target cells. As the sole viral protein on the HIV surface, Env is important both for immune responses to HIV and in vaccine designs. Targeting Env in clinical applications is challenging due to its heavy glycosylation, high genetic variability, conformational camouflage, and its low abundance on virions. Thus, there is a critical need to better understand this protein. Flow virometry (FV) is a useful metho… Show more
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