Applied Systems Biology—embracing molecular imaging for systemic medicine

Hacker, Marcus; Hicks, Rodney J.; Beyer, Thomas

doi:10.1007/s00259-020-04798-8

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…In addition to the higher sensitivity, another important advantage of TB PET scanners is the possibility of simultaneous imaging of multiple organs. This fosters dynamic whole-body imaging, aiding a better understanding of tracer distribution and enables organ axis imaging [ 15 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…This decrease of sensitivity is compensated by overlapping bed positions in multi-bed examinations or continuous-bed-motion (CBM) techniques to cover extended areas [ 19 ]. In the case of TB PET, multi-bed examinations are no longer intended for a variety of applications [ 15 , 17 ], hence the sensitivity reduction at the axial ends must be considered when extended areas are investigated.…”

Section: Introductionmentioning

confidence: 99%

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Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

et al. 2022

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Aim Recently, total-body PET/CT systems with an extended axial field-of-view (aFOV) became commercially available which allow acquiring physiologic information of multiple organs simultaneously. However, the nominal aFOV may clinically not be used effectively due to the inherently reduced sensitivity at the distal ends of the aFOV. The aim of this study was to assess the extent of the useful aFOV of the Biograph Vision Quadra PET/CT system. Methods A NEMA image quality (IQ) phantom mimicking a standard [18F]FDG examination was used. Image contrast and noise were assessed across the 106 cm aFOV of the Biograph Vision Quadra PET/CT system (Siemens Healthineers). Phantom acquisitions were performed at different axial positions. PET data were rebinned to simulate different acquisition times for a standard injected activity and reconstructed using different filter settings to evaluate the noise and images along the axial direction. Results Image noise and contrast were stable within the central 80 cm of the aFOV. Outside this central area, image contrast variability as well as image noise increased. This degradation of IQ was in particular evident for short acquisition times of less than 30 s. At 10 min acquisition time and in the absence of post-reconstruction filtering, the useful aFOV was 100 cm. For a 2 min acquisition time, a useful aFOV with image noise below 15% was only achievable using Gaussian filtering with axial extents of between 83 and 103 cm when going from 2 to 6 mm full-width-half-maximum, respectively. Conclusion Image noise increases substantially towards the ends of the aFOV. However, good IQ in compliance with generally accepted benchmarks is achievable for an aFOV of > 90 cm. When accepting higher image noise or using dedicated protocol settings such as stronger filtering a useful aFOV of around 1 m can be achieved for a 2 min acquisition time.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

et al. 2022

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“…data. Building on the success of radiogenomics in combining diverse imaging and genomics data for several applications, advanced machine learning algorithms have been suggested to further bridge the gap between imaging and multi-omics to enable a more comprehensive assessment of diseases [62]. Though this will require the future medical physicists to step even more outside of their comfort zone, it will also give them the unique opportunity to expand their role and become indispensable members of the larger community.…”

Section: Combined or Hybrid Imaging And Related Physicsmentioning

confidence: 99%

Medical Physics and Imaging–A Timely Perspective

et al. 2021

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“…To date, advances in molecular imaging, the availability of large human omic datasets and bioinformatic tools have equipped researchers to understand molecular processes that cause disease, and identify and develop new therapeutics (1) . However, to understand complex physiological and pathological interactions we need to employ system level approaches.…”

Section: Main Textmentioning

confidence: 99%

A systems-level analysis of dynamic total-body PET data reveals complex skeletal energy metabolism networksin vivo

Suchacki

Alcaide-Corral

Nimale

et al. 2021

Preprint

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Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary, limiting our ability to assess systemic mechanisms underlying diseases and develop novel therapeutics. In vitro molecular biology and bioinformatics approaches have frequently been used to understand the mechanistic changes underlying disease at the cell level, however, these approaches lack the capability to interrogate dynamic multi-bone metabolic interactions in vivo. Here we present a novel and integrative approach to understand complex bone metabolic interactions in vivo using total-body positron emission tomography (PET) network analysis of murine 18F-FDG scans, as a biomarker of glucose metabolism signature in bones. In this report we show that different bones within the skeleton have a unique glucose metabolism and form a complex metabolic network. These data could have important therapeutic implications in the management of the metabolic syndrome and skeletal disease. The application of our approach to clinical and preclinical total-body PET studies promises to reveal further physiological and pathological tissue interactions, which simplistic PET standard uptake values analysis fail to interrogate, extending beyond skeletal metabolism, due to the diversity of PET radiotracers available and under development as well as the advent of clinical total-body PET systems.

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Applied Systems Biology—embracing molecular imaging for systemic medicine

Abstract: This article is part of the Topical Collection on Editorial

Cited by 9 publications

References 16 publications

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

Image quality assessment along the one metre axial field-of-view of the total-body Biograph Vision Quadra PET/CT system for 18F-FDG

Medical Physics and Imaging–A Timely Perspective

A systems-level analysis of dynamic total-body PET data reveals complex skeletal energy metabolism networksin vivo

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