Applied biocatalysis in deep eutectic solvents

Paul, Caroline E.; Gotor‐Fernández, Vicente

doi:10.1016/b978-0-323-91306-5.00011-x

Cited by 5 publications

(3 citation statements)

References 108 publications

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“…Biocatalysis, the use of biological catalysts for the generation of many different valuable products, has proven to be a very useful tool, not only in the lab [158][159][160] but also at an industrial scale [161][162][163], undoubtedly fostered by the inherent sustainability associated with biocatalysis [164][165][166]. Additionally, the well-reported capability of enzymes to work in media different from water [167][168][169], and particularly in DESs [119,[170][171][172][173], has expanded their applicability, up to the point that some authors are pointing towards a golden age for biocatalysis [174].…”

Section: Biocatalysis For Chitin/chitosan Modificationsmentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

Catalysts

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Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, and versatile properties. Deep eutectic solvents (DESs), emerging green solvents composed of eutectic mixtures of hydrogen bond acceptors and donors, offer promising avenues for enhancing the solubility and functionality of chitin and chitosan in pharmaceutical formulations. This review delves into the potential of utilizing DESs as solvents for chitin and chitosan, highlighting their efficiency in dissolving these polymers, which facilitates the production of novel drug delivery systems, wound dressings, tissue engineering scaffolds, and antimicrobial agents. The distinctive physicochemical properties of DESs, including low toxicity, low volatility, and adaptable solvation power, enable the customization of chitin and chitosan-based materials to meet specific pharmaceutical requirements. Moreover, the environmentally friendly nature of DESs aligns with the growing demand for sustainable and eco-friendly processes in pharmaceutical manufacturing. This revision underscores recent advances illustrating the promising role of DESs in evolving the pharmaceutical applications of chitin and chitosan, laying the groundwork for the development of innovative drug delivery systems and biomedical materials with enhanced efficacy and safety profiles.

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Section: Biocatalysis For Chitin/chitosan Modificationsmentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

Catalysts

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“…These values increase more drastically when the topic is expanded to chemo catalysis in DESs, which is beyond the scope of this review and therefore not shown. A variety of biotransformations have been established in DESs to synthesize high-value chemicals using hydrolases, oxidoreductases, lyases, and amine transaminases, wherein DESs may function as solvents, cosolvents, additives, or even as substrates [67][68][69][70]. Rational design of customized DES for biocatalytic applications requires a holistic consideration of several aspects, including water content to retain enzyme activity, polarity to solubilize reactants, and viscosity to enable practical operation.…”

Section: Introductionmentioning

confidence: 99%

Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

Zhang,

Domínguez de María,

Kara

2024

Catalysts

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Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis.

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“…Owing to the vast variety of possible HBDs and HBAs, the possibility of changing the components’ ratio, and the amount of external water added, the potential number of combinations is immense, which confers them a high degree of tunability . Moreover, it is possible to appropriately select the components to prepare non-toxic and highly biodegradable DESs. , These solvents have nowadays a wide range of applications ranging from solvents for reactions, extraction, gas capture and separation, and (bio)catalysis. − The remaining challenges for DESs are mainly associated with their high viscosity, which affects the mass transfer in the reaction and adds complexity to the downstream processing. Moreover, a deep understanding about the relationship between the structure of its constituents and the solvent properties of DESs is still in its infancy .…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvents for the Enzymatic Synthesis of Sugar Esters: A Generalizable Strategy?

Semproli

Chanquia

Bittner

et al. 2023

ACS Sustainable Chem. Eng.

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Sugar (fatty acid) esters are industrially relevant compounds, with a cumbersome production process due to the solubility issues of the substrates, which forces the use of environmentally unfriendly reaction media. Herein, deep eutectic solvents (DESs) are considered as a promising solution: several literature examples use glucose and different acyl donors to illustrate the efficient synthesis of sugar esters in classic DESs like choline chloride/urea (ChCl/U). However, this paper discloses that when sugars like lactose or other disaccharides are used, enzymes cannot efficiently perform (trans)esterifications in DESs, while the same reaction can proceed in mixtures like pyridine/ tetrahydrofuran (Py/THF). This could be explained by computational solubility studies and molecular dynamics simulations of both reaction media, showing two effects: (i) on the one hand, large acyl donors (more than C10) display poor solubility in DESs and (ii) on the other hand, disaccharides interact with DES components. Thus, the DES affects the conformation of lactose (compared to the conformation observed in the Py/THF mixture), in such a way that the enzymatic reaction results impaired. Despite that classic DESs (e.g., ChCl/U) may not be useful for generalizing their use in saccharide ester syntheses, the achieved theoretical understanding of the reaction may enable the design of future DESs that can combine enzyme compatibility with ecofriendliness and efficiency in sugar chemistry.

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Applied biocatalysis in deep eutectic solvents

Cited by 5 publications

References 108 publications

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects

Deep Eutectic Solvents for the Enzymatic Synthesis of Sugar Esters: A Generalizable Strategy?

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