Applications to Biochemical Investigations

Thayer, John S.

doi:10.1016/b978-0-12-686080-1.50009-7

Cited by 2 publications

(1 citation statement)

References 317 publications

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“…The biological effects produced by metal ions are often significantly altered by complex ation of the metal, chelation within various organic matrices or actual covalent binding of the metal atom to organic substituents [1,2]. Furthermore, the toxicological effects pro duced by certain metals such as lead, arsenic, mercury' and tin are often greatly enhanced by the formation of organometallic compounds [3][4][5][6], Association of metal ions within organic matrices can shift the tissue site of action, alter the temporal response or modify the doseresponse associated with the organic metal, thus altering its biological potency.…”

Section: Introductionmentioning

confidence: 99%

The Comparative Abilities of Inorganic Cobalt and Cobalt-Protoporphyrin to Affect Copper Metabolism and Elevate Plasma Ceruloplasmin

Rosenberg

Kappas²

1995

Pharmacology

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A comparison of the effects of the trace element cobalt and the protoporphyrin chelate of this metal, cobalt-protoporphyrin, on copper and zinc metabolism in male Sprague-Dawley rats was made. Following subcutaneous treatment (250 µmol/kg body weight), inorganic cobalt elicited only a moderate (25-30%) and transient (48 h) increase in plasma copper levels and a concomitant elevation (up to 2-fold) in ceruloplasmin (ferroxidase) activity. Treatment with cobalt-protoporphyrin (25 µmol/kg), however, produced substantial (2- to 3-fold) and prolonged (up to 4 weeks) increases in plasma copper levels and ceruloplasmin. This effect on ceruloplasmin was specific to cobalt-protoporphyrin, since equimolar doses (25 µmol/kg body weight) of both tin-protoporphyrin and iron-protoporphyrin did not produce changes in the levels of circulating ceruloplasmin. Both inorganic cobalt and cobalt-protoporphyrin produced an elevation in liver cytosolic zinc levels at 48 h. This zinc associated with a fraction that coelutes with authentic metallothionein standard. These differential effects of inorganic cobalt and cobalt-protoporphyrin on copper and zinc metabolism represent newly defined biological properties of this trace element and point to the importance of chemical speciation as an underlying factor in the ultimate biological actions of metals.

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Section: Introductionmentioning

confidence: 99%

The Comparative Abilities of Inorganic Cobalt and Cobalt-Protoporphyrin to Affect Copper Metabolism and Elevate Plasma Ceruloplasmin

Rosenberg

Kappas²

1995

Pharmacology

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Accumulation and toxic effect of organometallic compounds on algae

Huang

Zhang

Dai

et al. 1993

Applied Organom Chemis

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This paper reports toxic effects and bioaccumulation factors of organometallic compounds, mainly organotin species, on algae. We selected two species of microalgae as test algae: one was Scenedesmus obliquus as a representative of freshwater algae, the other Dunaliella salina and Dunaliella uiridis, to represent commonly mixed algae which exist abundantly in Tianjin Harbor, People's Republic of China. For comparison, Chlorella uulgaris was also used in this study. The toxic effect of ten organometallic compounds on the freshwater alga, S . obliquus, was investigated. The ten compounds were (as chlorides) tributyltin (TBT); triphenyltin (TPT); trimethyltin (TMT); dibutyltin (DBT); diphenyltin (DPT); dimethyltin (DMT); trimethyl-lead acetate (TML); dimethylarsine (DMA) and two new mixed-alkyltin pesticides, dicyclohexylmethyltin acetate (Cy2MTA) and dicyclohexylmethyltin isobutyrate (Cy2MTB). The order of toxicity of these compounds in fresh- TBT was metabolized by algae to a less toxic * Author to whom correspondence should be addressed product, DBT. The existence of algal cells accelerated the concentration reduction of TBT. The toxic mechanism of TBT was also studied.

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Applications to Biochemical Investigations

Cited by 2 publications

References 317 publications

The Comparative Abilities of Inorganic Cobalt and Cobalt-Protoporphyrin to Affect Copper Metabolism and Elevate Plasma Ceruloplasmin

The Comparative Abilities of Inorganic Cobalt and Cobalt-Protoporphyrin to Affect Copper Metabolism and Elevate Plasma Ceruloplasmin

Accumulation and toxic effect of organometallic compounds on algae

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