Applications of yeast in drug discovery

Effect ofin vitrodigested cod liver oil of different quality on oxidative, proteomic and inflammatory responses in the yeastSaccharomyces cerevisiaeand human monocyte-derived dendritic cells

“…To study the effect of digested cod liver oil with varying amounts of lipid oxidation products in the yeast cell, Saccharomyces cerevisiae , was used, which is an appropriate model organism to study fundamental eukaryotic cellular processes, such as stress responses and metabolic pathways . After 2 h exposure of yeast cells to in vitro digests, intracellular oxidation, cell energy metabolic activity and mitochondrial proteome were analysed.…”

A history of research on yeasts 10: foundations of yeast genetics1

“…The genetic tractability of S. cerevisiae and its non‐pathogenic character has made it attractive for elucidating cellular biochemistry and facilitating the molecular analysis of genes which cause diseases. It is used for testing antifungal products and other new drugs228. Such practical advances have been made possible by academic research on heredity in plants, such as that by Mendel, on yeast genetics, such as that by Winge, as well as research by thousands of other scientists, too numerous to mention here.…”

Perchance to dream: Solving the mystery of sleep through genetic analysis

“…Publication of the human genome project in 2000 along with the publication of several other genome projects has resulted in an increased interest in using genetics to solve previously intractable problems. Indeed, important insights into many human diseases have come from model systems such as yeast, the flat worm, the fruit fly, and the mouse (Hamilton and Frankel 2001;Kuwabara and O'Neil, 2001;Ma, 2001;Muqit and Feany, 2002). These organisms have become vital tools for many laboratories investigating complex phenomena (this issue).…”