Applications of Systems Biology to Identify Mechanisms of Adaptive Response to Targeted Single and Combinatorial Drug Treatment in Cancer

Abstract

"There are three kinds of lies: lies, damned lies, and statistics." Attributed to Benjamin Disraeli, popularized by Mark TwainThis dissertation is dedicated to my wife, because she supported me through the struggles of being a graduate student, and my family, who have supported me through the Herculean amount of schooling I have chosen to undertake. 3 AcknowledgementsI wish to first acknowledge both Aaron Mackey and Stefan Bekiranov.Aaron was magnanimous enough to teach me how to leverage computer programming as a biologist, while I had almost no experience with programming languages. He sat me down whenever was required and gave excellent guidance on how to track down the last little bug in the code. Additionally, he taught me the