Applications of synchrotron X-rays to radiotherapy

Blattmann, H.; Gebbers, Jan‐Olaf; Bräuer-Krisch, Elke; Bravin, A.; Duc, Géraldine Le; Burkard, W. P.; Michiel, Marco Di; Djonov, Valentin; Slatkin, Daniel N.; Stĕpánek, J.; Laissue, Jean A.

doi:10.1016/j.nima.2005.03.060

Cited by 72 publications

(64 citation statements)

References 19 publications

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“…One hypothesis that has received experimental support is the rapid regeneration of normal microvessels damaged in the direct paths of thin MBs (1,6,10,16). The MBs' preferential tumoricidal effects, or strong tumor palliation properties, are due, in part, to the lack of recovery of the tumor vasculature l (2,7,8), presumably because of structural differences between microvessels of tumor and those of the surrounding normal tissue (17).…”

mentioning

confidence: 99%

Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential

Dilmanian

Zhong²,

Bacarian³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

175

214

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Studies have shown that x-rays delivered as arrays of parallel microplanar beams (microbeams), 25-to 90-m thick and spaced 100 -300 m on-center, respectively, spare normal tissues including the central nervous system (CNS) and preferentially damage tumors. However, such thin microbeams can only be produced by synchrotron sources and have other practical limitations to clinical implementation. To approach this problem, we first studied CNS tolerance to much thicker beams. Three of four rats whose spinal cords were exposed transaxially to four 400-Gy, 0.68-mm microbeams, spaced 4 mm, and all four rats irradiated to their brains with large, 170-Gy arrays of such beams spaced 1.36 mm, all observed for 7 months, showed no paralysis or behavioral changes. We then used an interlacing geometry in which two such arrays at a 90°angle produced the equivalent of a contiguous beam in the target volume only. By using this approach, we produced 90-, 120-, and 150-Gy 3.4 ؋ 3.4 ؋ 3.4 mm 3 exposures in the rat brain. MRIs performed 6 months later revealed focal damage within the target volume at the 120-and 150-Gy doses but no apparent damage elsewhere at 120 Gy. Monte Carlo calculations indicated a 30-m dose falloff (80 -20%) at the edge of the target, which is much less than the 2-to 5-mm value for conventional radiotherapy and radiosurgery. These findings strongly suggest potential application of interlaced microbeams to treat tumors or to ablate nontumorous abnormalities with minimal damage to surrounding normal tissue.

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mentioning

confidence: 99%

Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential

Dilmanian

Zhong²,

Bacarian³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

175

214

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“…The exceptional resistance of the normal-tissue to high dose microbeam irradiation with no evidence of late tissue effects [12,22,23,24] lead to the development of a new concept in radiobiology, the tissue sparing effect, described in the next paragraph.…”

Section: Radiobiology Of Central Nervous System Microbeam Irradiationmentioning

confidence: 99%

“…Only a short segment of the microvascular bed receives ablating doses while the adjacent endothelial cells fall into the valley dose region receiving just a few Gy and can restore quickly the continuity of vascular supply [24]. The wide spatial interface between the unhindered tissue placed in the valleys and the tissue irradiated with peak doses within the microbeam paths facilitates a widespread vascular recolonization of the tissue receiving necrotic doses preventing the dissolution of the architecture of the irradiated tissues [3].…”

Section: Microbeam Radiosurgerymentioning

confidence: 99%

“…MRT irradiation has been carried out to deliver very high radiation doses into tumours in a single fraction through an unidirectional approach [11,15]. Most of the experimental activity performed until now has been focused on the study of the effects of arrays of parallel microbeams [4,5,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][28][29][30]. MRT has been applied to several tumor models including intracerebral gliosarcoma (9LGS) in rats [11,13,30], murine mammary carcinoma (EMT-6) [19] and human squamous-cell carcinoma (SCCVII) in mouse and rat [9,20].…”

Section: Microbeam Radiosurgerymentioning

confidence: 99%

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Emerging neurosurgical applications of synchrotron-generated microbeams

Romanelli¹,

Fardone²,

Bräuer-Krisch³

et al. 2011

Cureus

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“…The first experiment hutch (1B) is designed to be the primary radiotherapy research facility. Intense beams will be available in this hutch to deliver the very high dose rates required for some of the radiotherapy research projects such as micro beam radiation therapy (3). A bright monochromatic beam will also be available in this hutch derived from a double Laue monochromator situated in the optics hutch 1A.…”

Section: Beam Line Descriptionmentioning

confidence: 99%