Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue engineering

Davies, Owen R.; Lewis, Andrew L.; Whitaker, Martin J.; Tai, Hongyun; Shakesheff, Kevin M.; Howdle, Steven M.

doi:10.1016/j.addr.2006.12.001

Cited by 257 publications

(164 citation statements)

References 106 publications

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“…This rather long soaking time is most probably due to the high crystallinity of PCL10 (around 52% by DSC). It is well known that CO 2 is able to diffuse and dissolve only in the amorphous regions of polymers [5,18,58], and that the T m depression is given by both polymer-CO 2 interactions in the amorphous regions and crystallites characteristics (e.g. lamellar thickness and heat of fusion per unit of volume); hence, different effects will be expected for different levels of amorphous fractions [18,58].…”

Section: Effect Of Pressure On T M Of Pcl10mentioning

confidence: 99%

“…In recent years there has been increasing interest in the use of high-pressure CO 2 as a reaction medium or plasticiser for polymer synthesis and processing [1][2][3][4][5][6]. CO 2 has been exploited as a solvent for polymerisations [7,8], as a foaming agent [1,[9][10][11][12][13], for precipitation/separation [14], particle formation [15,16] and encapsulation [17].…”

Section: Introductionmentioning

confidence: 99%

“…The CO 2 -induced plasticisation mimics the effect of heating the polymer and it is characterised by an increased segmental and chain mobility [29]: the CO 2 molecules exhibit significant specific interactions with many polymers, mainly due to their large quadrupole moment [5,30]. These interactions often results in high sorption levels and decrease the intermolecular bonding between the chains [31].…”

Section: Introductionmentioning

confidence: 99%

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High-pressure rheological analysis of CO2-induced melting point depression and viscosity reduction of poly(ε-caprolactone)

Curia

Focatiis

Howdle

2015

Polymer

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(2015) High-pressure rheological analysis of CO2-induced melting point depression and viscosity reduction of poly(ε-caprolactone). Polymer, Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/45413/1/curia_polymer2015_preprint.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Furthermore, a significant decrease in the viscosity of two PCL grades with different molecular weight (M n~1 0 kDa and 80 kDa) was also detected upon increasing the CO 2 pressure to 300 bar.Experimental viscosity data were fitted to the Carreau model to quantify the extent of the plasticising effects on the zero-shear viscosity and relaxation time under different conditions. Similar analyses were conducted under high-pressure nitrogen, to compare the effects obtained in the presence of a non-plasticising gas.

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Section: Effect Of Pressure On T M Of Pcl10mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High-pressure rheological analysis of CO2-induced melting point depression and viscosity reduction of poly(ε-caprolactone)

Curia

Focatiis

Howdle

2015

Polymer

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“…PCL is a biodegradable aliphatic polyester that is being commonly used for biomedical applications due to its biocompatibility and biodegradability, mainly for the preparation of drug delivery devices and tissue engineering scaffolds [3][4][5]. Therefore, the processing of PCL with scCO 2 has been widely analyzed, starting from the basic research on the thermodynamic and mass transport properties of the specific binary system [6,7].…”

Section: Introductionmentioning

confidence: 99%

Anomalous swelling of molten PCL/scCO2 solutions

Carbone

Tammaro

Maio

et al. 2014

AIP Conference Proceedings

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Abstract. The swelling behavior of molten poly(ε-caprolactone) in contact with carbon dioxide has been analyzed by using the pendant drop method. At subcritical pressures, the swelling kinetics of the polymer-gas solution follow the typical Fickian diffusion behavior, the volume approaching an equilibrium value after the initial transient. In supercritical conditions, after the first transient, the volume of the solution does not approach an equilibrium value but still, slowly increases. Raman experiments have suggested that this anomalous time-dependent swelling in scCO 2 could be due or to slow, secondary diffusion, or to polymer dissolution in scCO 2 .

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“…13 CO 2 supercritical fluid is the best choice, from among the others available for pharmaceutical processes, as it is affordable, nontoxic, and inflammable. Further, it has high volatility, mild critical temperature (304°K), low critical pressure (7.38 MPa), low cohesive energy density, low polarizability per unit volume, and poor solubility for many polymers and drugs, 8,10,13,15,16 and it has low viscosity like a gas, although its density is similar to that of a liquid. Around the critical point, its properties such as density, viscosity, solvency, and diffusivity can be manipulated by adjusting the pressure and temperature.…”

Section: Introductionmentioning

confidence: 99%

Application of supercritical antisolvent method in drug encapsulation: a review

Kalani¹,

Yunus²

2011

IJN

114

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The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO 2 flow rate, and the liquid phase flow rate on particle size and its distribution.

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Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue engineering

Cited by 257 publications

References 106 publications

High-pressure rheological analysis of CO2-induced melting point depression and viscosity reduction of poly(ε-caprolactone)

High-pressure rheological analysis of CO2-induced melting point depression and viscosity reduction of poly(ε-caprolactone)

Anomalous swelling of molten PCL/scCO2 solutions

Application of supercritical antisolvent method in drug encapsulation: a review

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