Applications of stimuli-responsive nanoscale drug delivery systems in translational research

Gu, Meijia; Wang, Xin; Toh, Tan Boon; Chow, Edward Kai‐Hua

doi:10.1016/j.drudis.2017.11.009

Cited by 90 publications

(52 citation statements)

References 75 publications

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“…In the past several decades, together with the improvement of nanotechnology and material science, various so-called stimuli responsive carriers have been successfully developed as promising vectors for drug delivery, i.e., so that the encapsulated therapeutics molecules could be released in a spatial or temporal ("smart") delivery systems (Gu et al, 2018). Among the external stimuli, pulsed electric fields, as the ones used for electroporation of cells seem a promising technique to activate lipid vesicles carriers thus achieving a stimulus-sensitivity delivery of the payload encapsulated inside them.…”

Section: Discussionmentioning

confidence: 99%

Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments

Caramazza

Nardoni

Angelis

et al. 2020

Front. Bioeng. Biotechnol.

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Section: Discussionmentioning

confidence: 99%

Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments

Caramazza

Nardoni

Angelis

et al. 2020

Front. Bioeng. Biotechnol.

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“…In this delivery mode, certain RNAs, proteins, lipids, carbohydrates, and small metabolite molecules are used as biomarkers to reach particular target sites (Conte et al, 2017). Selective targeting to specific tissues or body sites also becomes possible in this therapeutic modality by incorporating specific stimuliresponsive components which can be triggered by particular stimuli such as electric or magnetic field, light, pH, heating, ultrasound, and also by contact with concentrated ionic solutions or certain enzymes (Gu et al, 2018). Moreover, there exists a possibility to modify the physical surface properties of metallic nanoparticles, such as silver, gold, and iron oxide nanoparticles, so that they act as drug carriers by the active delivery mode (Kong et al, 2017).…”

Section: Therapeutic Advantages Of Nanodelivery Systemsmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

143

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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“…Inherent fluorescence of FNDs has also been explored as alternative options primarily for biomedical imaging and diagnostic applications, but also has potential as a platform for drug delivery . For both DNDs and FNDs, the advantages of nanodiamonds toward both drug delivery and imaging also support potential of applying NDs toward the emerging fields of theranostics and stimuli‐responsive drug delivery and imaging . Whether used alone as a platform for drug delivery or in combination with other materials, NDs are poised to transform medicine.…”

Section: Biomedical Applications Of Nanodiamondsmentioning

confidence: 99%

Clinical Applications of Carbon Nanomaterials in Diagnostics and Therapy

et al. 2018

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Nanomaterials have the potential to improve how patients are clinically treated and diagnosed. While there are a number of nanomaterials that can be used toward improved drug delivery and imaging, how these nanomaterials confer an advantage over other nanomaterials, as well as current clinical approaches is often application or disease specific. How the unique properties of carbon nanomaterials, such as nanodiamonds, carbon nanotubes, carbon nanofibers, graphene, and graphene oxides, make them promising nanomaterials for a wide range of clinical applications are discussed herein, including treating chemoresistant cancer, enhancing magnetic resonance imaging, and improving tissue regeneration and stem cell banking, among others. Additionally, the strategies for further improving drug delivery and imaging by carbon nanomaterials are reviewed, such as inducing endothelial leakiness as well as applying artificial intelligence toward designing optimal nanoparticle-based drug combination delivery. While the clinical application of carbon nanomaterials is still an emerging field of research, there is substantial preclinical evidence of the translational potential of carbon nanomaterials. Early clinically trial studies are highlighted, further supporting the use of carbon nanomaterials in clinical applications for both drug delivery and imaging.

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Applications of stimuli-responsive nanoscale drug delivery systems in translational research

Cited by 90 publications

References 75 publications

Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments

Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Clinical Applications of Carbon Nanomaterials in Diagnostics and Therapy

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