Applications of stimulated Raman scattering (SRS) microscopy in materials science

Cheng, Qian; Miao, Yupeng; Zhang, Ruiwen; Min, Wei; Yang, Yuan

doi:10.1016/b978-0-323-85158-9.00016-6

Cited by 26 publications

(36 citation statements)

References 62 publications

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“…Importantly, IR absorption offers 8 orders of magnitude larger cross section (∼10 –22 cm 2 sr –1 ) that enables adequate sensitivity. Based on IR spectroscopy, the Fourier transform infrared (FTIR) microscopy has been developed for spatially resolved chemical information on biological samples. − Despite the well-established modality and wide applications, FTIR imaging is limited to spectral acquisition over a large bandwidth, even when only a few bands are of interest . Quantum cascade laser (QCL)-based discrete frequency IR imaging can select specific vibration bands, providing rapid chemical imaging of a specimen .…”

Section: Introductionmentioning

confidence: 99%

Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications

et al. 2022

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Midinfrared photothermal (MIP) microscopy, also called optical photothermal infrared (O-PTIR) microscopy, is an emerging tool for bond-selective chemical imaging of living biological and material samples. In MIP microscopy, a visible probe beam detects the photothermal-based contrast induced by a vibrational absorption. With submicron spatial resolution, high spectral fidelity, and reduced water absorption background, MIP microscopy has overcome the limitations in infrared chemical imaging methods. In this review, we summarize the basic principle of MIP microscopy, the different origins of MIP contrasts, and recent technology development that pushed the resolution, speed, and sensitivity of MIP imaging to a new stage. We further emphasize its broad applications in life science and material characterization, and provide a perspective of future technical advances.

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Section: Introductionmentioning

confidence: 99%

Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications

et al. 2022

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“…For a more comprehensive description of the optics and associated mathematics, readers are encouraged to refer to the specialist books and journal publications. 24–26…”

Section: Introductionmentioning

confidence: 99%

Practical considerations for quantitative and reproducible measurements with stimulated Raman scattering microscopy

Tsikritsis

Legge

Belsey

2022

Analyst

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“…Researchers have recently identified targeting the rat sarcoma virus (RAS) and tyrosine kinase signaling pathways, ephrin receptor subfamily of the protein-tyrosine kinase family (EPH3A) and EGFR receptors, and the development of monoclonal antibody bevacizumab as the means to halt the progression of GBM ( Mao et al, 2012 ; Pearson & Regad, 2017 ). Unfortunately, the recurrence of GBM tumors remains a major limiting factor for all the existing primary treatment strategies ( Shergalis et al, 2018 ; Cheng et al, 2021 ). Thus, there is an unmet need to identify molecular drivers responsible for the progression of GBM.…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiling of Glioblastoma to Recognize Potential Biomarker Candidates

Aishwarya²,

et al. 2022

Front. Genet.

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Glioblastoma is an aggressive malignant tumor of the brain and spinal cord. Due to the blood–brain barrier, the accessibility of its treatments still remains significantly challenging. Unfortunately, the recurrence rates of glioblastoma upon surgery are very high too. Hence, understanding the molecular drivers of disease progression is valuable. In this study, we aimed to investigate the molecular drivers responsible for glioblastoma progression and identify valid biomarkers. Three microarray expression profiles GSE90604, GSE50601, and GSE134470 containing healthy and glioblastoma-affected samples revealed overlapping differentially expressed genes (DEGs). The interrelational pathway enrichment analysis elucidated the halt of cell cycle checkpoints and activation of signaling pathways and led to the identification of 6 predominant hub genes. Validation of hub genes in comparison with The Cancer Genome Atlas datasets identified the potential biomarkers of glioblastoma. The study evaluated two significantly upregulated genes, SPARC (secreted protein acidic and rich in cysteine) and VIM (vimentin) for glioblastoma. The genes CACNA1E (calcium voltage-gated channel subunit alpha1 e), SH3GL2 (SH3 domain-containing GRB2-like 2, endophilin A1), and DDN (dendrin) were identified as under-expressed genes as compared to the normal and pan-cancer tissues along with prominent putative prognostic biomarker potentials. The genes DDN and SH3GL2 were found to be upregulated in the proneural subtype, while CACNA1E in the mesenchymal subtype of glioblastoma exhibits good prognostic potential. The mutational analysis also revealed the benign, possibly, and probably damaging substitution mutations. The correlation between the DEG and survival in glioblastoma was evaluated using the Kaplan–Meier plots, and VIM had a greater life expectancy of 60.25 months. Overall, this study identified key candidate genes that might serve as predictive biomarkers for glioblastoma.

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Applications of stimulated Raman scattering (SRS) microscopy in materials science

Cited by 26 publications

References 62 publications

Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications

Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications

Practical considerations for quantitative and reproducible measurements with stimulated Raman scattering microscopy

Gene Expression Profiling of Glioblastoma to Recognize Potential Biomarker Candidates

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