Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine

Abstract

Zeolitic Imidazolate Framework-8 (ZIF-8) is a type of typical metal organic framework (MOF), which is an emerging porous coordination polymers that is bridged by zinc metal ions and organic linkages. Due to its intrinsic porous characteristics, unique pH sensitivity as well as superior drug loading efficiency, zeolitic imidazolate framework-8 has attracted extensive attention and received a wide range of applications in the field of biomedicine. In this review, we briefly discuss the effective delivery and controlled release of various drugs in ZIF-8, such as functional proteins, hydrophilic and hydrophobic drugs. Understanding the processes of various drugs loading is important for developing new drug delivery systems. In addition, we also explored the cooperation mechanism between ZIF and different materials. The combination of chemotherapy, photodynamic therapy, photothermal therapy and medical imaging have been applied in the field of nanomedicine and have made emarkable achievements.

Efficient Isolation and In Situ Identification of Viable Circulating Tumor Cells Using Dual‐Responsive Fluorescent‐Magnetic Nanoparticles

“…Inspired by these characteristics, ZIF-8 appears to be an ideal vector in encapsulating imaging agents and disassembling under pH/ATP stimuli. [27][28][29][30][31][32][33] Herein, we developed a multifunctional platform based on pH/ATP-responsive fluorescent-magnetic Fe 3 O 4 /Rhm B@ZIF-8-pTA nanoparticles (FR@Z-pTA NPs) for efficiently isolating heterogeneous CTCs (Scheme 1). FR@Z-pTA NPs were prepared by successively constructing Rhm B-encapsulated ZIF-8 shell and poly(tannic acid) (pTA) coating on the surface of superparamagnetic Fe 3 O 4 nanoparticles through one-step self-assembly method and enzyme-catalyzed oxidative polymerization.…”

“…Inspired by these characteristics, ZIF‐8 appears to be an ideal vector in encapsulating imaging agents and disassembling under pH/ATP stimuli. [ 27–33 ]…”