Applications of Scanning Probe Microscopy and Nanomechanical Analysis in Pharmaceutical Development

Lamm, Matthew S.

doi:10.1002/9781118723111.ch13

Cited by 1 publication

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The technique has been used widely in the polymer field (5) over the past two decades for evaluating systems such as polymer blends (6,7), block copolymers (8,9), and nanocomposites (10,11). Beyond the polymer and plastic industries, the technique has been gaining popularity within the pharmaceutical field for the characterization of amorphous solid dispersions (12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Assessing Mixing Quality of a Copovidone-TPGS Hot Melt Extrusion Process with Atomic Force Microscopy and Differential Scanning Calorimetry

et al. 2015

Self Cite

View full text Add to dashboard Cite

Abstract. Atomic force microscopy (AFM) and modulated differential scanning calorimetry (mDSC) were used to evaluate the extent of mixing of a hot melt extrusion process for producing solid dispersions of copovidone and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS 1000). In addition to composition, extrusion process parameters of screw speed and thermal quench rate were varied. The data indicated that for 10% TPGS and 300 rpm screw speed, the mixing was insufficient to yield a singlephase amorphous material. AFM images of the extrudate cross section for air-cooled material indicate round domains 200 to 700 nm in diameter without any observed alignment resulting from the extrusion whereas domains in extrudate subjected to chilled rolls were elliptical in shape with uniform orientation. Thermal analysis indicated that the domains were predominantly semi-crystalline TPGS. For 10% TPGS and 600 rpm screw speed, AFM and mDSC data were consistent with that of a single-phase amorphous material for both thermal quench rates examined. When the TPGS concentration was reduced to 5%, a single-phase amorphous material was achieved for all conditions even the slowest screw speed studied (150 rpm).

show abstract